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Table 3 Minimum inhibitory concentrations (MICs) of meropenem alone and in combination with coumarin and FIC index

From: Phenotypic, molecular, and in silico characterization of coumarin as carbapenemase inhibitor to fight carbapenem-resistant Klebsiella pneumoniae

Isolate’s code

Coumarin MIC (µg/mL)

MEM MIC (µg/mL)

MEM + coumarin

FIC index

500 µg/mL

1000 µg/mL

500 µg/mL

1000 µg/mL

1 K

≥ 8192

128

64

1

0.56

0.13

2 K

256

256

0.5

1.06

0.12

3 K

128

32

0.25

0.375

0.12

4 K

512

256

64

0.56

0.13

5 K

64

1

< 0.25

0.07

0.12

6 K

64

2

< 0.25

0.09

0.12

  1. MEM: Meropenem; FIC: Fractional Inhibitory Concentration
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BMC Microbiology

ISSN: 1471-2180

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