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Fig. 3 | BMC Microbiology

Fig. 3

From: Phenotypic, molecular, and in silico characterization of coumarin as carbapenemase inhibitor to fight carbapenem-resistant Klebsiella pneumoniae

Fig. 3

Effect of coumarin-meropenem combination on K. pneumonia isolates. (A) Checkerboard assay indicated a synergistic effect of coumarin-meropenem combination against carbapenemase positive K. pneumoniae isolates. The Fig. shows multiple possible combinations. The color gradient reflects the turbidity of bacterial culture (OD = 600 nm) (B) Inhibition zones surrounding meropenem disks on MH agar plates without and with two concentrations of coumarin (500 and 1000 µg/mL). (C) Coumarin significantly increased the diameter of bacterial growth inhibition zones surrounding meropenem disks relative to that of control without coumarin treatment. ***indicates P < 0.001

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BMC Microbiology

ISSN: 1471-2180

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