Fig. 6

The pathological changes of A. dhakensis HN-1 infected mice. (A, D) No obvious clinic symptoms and visible lesions in the negative control group; (B) Mental malaise, lethargy and tremor in the infected groups; (C) Swelling and hemorrhage in the spleen (yellow arrow) and kidney (green arrow); (E) Oedema with acute hemorrhage in the intestine wall (yellow arrow); (F) Hepatic oedema (yellow arrow), severe hemorrhage in the lung (blue arrow); (G) Intestine mucosal epithelial cells shedding (black arrow), capillary congestion expansion (yellow arrow), mucosal layer and submucosa infiltrated with a small amount of inflammatory cell (red arrow). (H) Spleen red pulp congestion; (I) Inflammatory cell infiltration around the hepatic portal area; (J) Mucosal epithelial cells arranged irregularly (yellow arrow), perivascular inflammatory cell infiltration (red arrow); (K-N) PBS control