Genetic diversity of macrolides resistant Staphylococcus aureus clinical isolates and the potential synergistic effect of vitamins, C and K3

El-Banna, Tarek El-Said; Sonbol, Fatma Ibrahim; Kamer, Amal M. Abo; Badr, Sara Ahmed Mohammed Mahmoud

doi:10.1186/s12866-023-03169-1

Table 6 Antimicrobial effect of combination between the vit C and Azythromycin

From: Genetic diversity of macrolides resistant Staphylococcus aureus clinical isolates and the potential synergistic effect of vitamins, C and K₃

Sample code	Mic of Vit c Alone	Mic of AZt Alone	\(\frac{1}{2}\) mic of Vit C + AZt	FICI	\(\frac{1}{4}\) mic of Vit C + AZt	FICI	\(\frac{1}{8}\) mic of Vit C + AZt	FICI
69 A	2000	1024	1024	1.5 No	1024	1.25 No	1024	1.125 No
36	2000	256	64	0.75 AD	256	1.25 No	256	1.25 No
103	1000	512	16	0.53 AD	32	0.31 S	64	0.25 S
24	1000	1024	1024	1.5 No	2048	2.25 NO	2048	2.125 NO
41 A	1000	1024	64	0.5 S	128	0.37 S	256	0.37 S
102	1000	16	8	1 add	16	1.25 No	32	2.125 NO
303	1000	512	1024	2.5 NO	1024	2.25 NO	2048	4.125 Anta
39 A	4000	512	512	1.5 No	1024	2.25 NO	1024	2.125 NO
311	4000	1024	32	0.5 S	64	0.31 S	128	0.25 S
G	2000	512	1024	2.5 NO	2048	4.25 Anta	2048	4.125 Amta
307	2000	1024	1024	1.5 No	2048	2.25 NO	2048	2.125 NO
80	2000	1024	1024	1.5 No	2048	2.25 NO	2048	2.125 NO
78 +	2000	256	1024	4.5 antag	2048	8.25 Antag	2048	8.125 Antag
50 A	2000	512	1024	2.5 NO	2048	4.25 Antag	2048	4.125 Antag
307	2000	512	64	0.6 add	64	0.375 Syn	512	1.125 No
302	2000	1024	32	0.53 SYN	1024	1.25 No	1024	1.125 No
82 A	2000	1024	1	0.5 S	2	0.251 S	4	0.128 S
40 A	1000	8	0.5	0.56 AD	0.5	0.312 S	2	0.315 S
44 A	1000	1024	8	0.50 S	0.5	0.25 S	512	0.5 S
10 A	2000	1024	0.5	0.5 S	0.5	0.5 S	1	0.25 S
32 A	2000	1024	0.5	0.5 S	0.5	0.25 S	1	0.126 S
67 A	2000	1024	256	0.75 AD	256	0.5 S	512	0.625 AD
ن	2000	1024	1024	1.5 No	1024	1.25 No	1024	1.125 No
202	2000	512	256	1 AD	256	0.75 AD	512	0.625 AD
89 +	2000	1024	0.5	0.5 S	1	0.25 S	2	0.126 S
86 A	2000	1024	8	0.50 S	256	0.5 S	512	0.63 ADD
F	2000	512	0.5	0.5 S	0.5	0.250 S	1	0.126 S
A	2000	1024	0.5	0.50 S	0.5	0.25 S	1	0.126 S
300	2000	1024	4	0.5 S	8	0.25 S	1	0.12 S
45 A	2000	512	4	0.5 S	8	0.26 S	1	0.12 S
28 A	2000	1024	8	0.5 S	0.5	0.5 S	1	0.125 S
300 +	2000	512	0.5	0.5 S	1	0.250 S	1	0.126 S
43 A	2000	4	8	0.5 S	8	0.25 S	1024	0.13 S
100	2000	8	16	1 add	8	1.25 No	16	0.62 AD
100 A	2000	8	0.25	0.5 S	2	0.25 S	1024	0.12 S
48 A	2000	256	512	0.75 AD	512	0.75 AD	1024	0.62 AD
46 A	2000	8	256	0.5 S	512	0.75 AD	1024	0.62 AD
4 A	2000	2	4	0.13 S	1	0.26 S	512	0.5 S
3 A	2000	0.5	0.5	0.5 S	1	0.25 S	1024	0.12 S
204	2000	8	16	1 AD	8	1.25 NO	16	0.62 AD
58	2000	8	0.5	0.5 S	2	S 0.25	1024	0.12 S
56 A	2000	4	8	S 0.5	16	0.25 S	1024	0.14 S
27 A	2000	1024	1024	1.5 no	1024	1.25 No	1024	1.125 No
89	2000	1024	1024	1.5 no	1024	1.25 No	1024	1.125 No
22	4000	1024	1024	1.5 No	2048	2.25 NO	2048	2.125 NO
90	4000	1024	1024	1.5 NO	2048	2.25 NO	2048	2.125 NO
38 A	4000	16	2	0.62 AD	2	0.37 S	4	0.37 S
78 A	500	1024	1024	1.5 no	2048	2.25antag	2048	2.125antag
1 A	500	1024	1024	1.5 Add	2048	2.25antag	2048	2.125antag
53	500	16	2	0.62 ADD	2	0.37 S	4	0.37 S

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ISSN: 1471-2180

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