Genetic diversity of macrolides resistant Staphylococcus aureus clinical isolates and the potential synergistic effect of vitamins, C and K3

El-Banna, Tarek El-Said; Sonbol, Fatma Ibrahim; Kamer, Amal M. Abo; Badr, Sara Ahmed Mohammed Mahmoud

doi:10.1186/s12866-023-03169-1

Table 4 Antimicrobial effect of combination between the vit K₃ and Azythromycin

From: Genetic diversity of macrolides resistant Staphylococcus aureus clinical isolates and the potential synergistic effect of vitamins, C and K₃

Sample code	Mic of Vit.K Alone	Mic of AZt Alone	\(\frac{1}{2}\) mic of Vit.K + AZt	FICI	\(\frac{1}{4}\) mic of Vit.K + AZt	FICI	\(\frac{1}{8}\) mic of Vit.K + AZt	FICI
27 A	64	1024	256	0.75 ADD	512	0.75 ADD	1024	1.12 IND
80	64	1024	2	0.5 S	4	0.25 S	8	0.13 S
18⁺	64	1024	1	0.5 S	2	0.25 S	4	0.13 S
317	64	512	2	0.5 S	512	1.25 IND	1024	2.125 IND
102	64	512	2	0.5 S	8	0.26 S	16	0.15 S
305	64	512	2	0.5 S	8	0.26 S	16	0.15 S
316	64	1024	1024	1.5 IND	1024	1.5 IND	1024	1.12 IND
7⁺	64	1024	1	0.5 S	2	0.25 S	8	0.132 S
83	64	16	0.5	0.5 S	0.5	0.28 S	32	2.1 IND
58	64	1024	1	0.5 S	2	0.25 S	4	0.13 S
44 A	64	1024	1	0.5 S	2	0.25 S	8	0.132 S
G	64	1024	0.5	0.5 S	1	0.25 S	2	0.126 S
307	64	1024	1024	1.5 IND	1024	1.5 IND	1024	1.12 IND
324	64	1024	0.5	0.5 S	1	0.25 S	2	0.12 S
316	64	512	1024	2.5 IND	2048	4.25 ANT	2048	4.12 ANT
75 A	64	1024	1024	1.5 IND	1024	1.25 IND	1024	1.12 IND
310	64	1024	8	0.5 S	4	0.25 S	2	1.126 IND
308	64	16	0.5	0.53 S	1	0.31 S	2	0.25 S
41 A	64	512	1024	2.5 IND	1024	2.25 IND	1024	2.1 IND
53	64	1024	0.5	0.5 S	1	0.25 S	2	0.12 S
303	64	1024	16	0.5 S	32	0.28 S	64	0.18 S
69 A	64	512	512	1.5 IND	1024	2.25 IND	1024	2.12 IND
78	64	1024	1024	1.5 IND	1024	1.25 IND	1024	1.125 IND
321	64	512	2	0.5 S	512	1.25 IND	1024	2.125 IND
46A	64	1024	1024	1.5 IND	1024	1.25 IND	2	0.12 S
300⁺	64	1024	2	0.5 S	4	0.25 S	8	0.13 S
38 A	64	512	2	0.5 S	8	0.26 S	16	0.15 S
100 A	64	1024	1024	1.5 IND	1024	1.25 IND	1024	1.125 IND
39 A	128	512	2	0.5 S	8	0.26 S	16	0.15 S
T	128	32	0.5	0.5 S	32	1.25 IND	32	1.125 IND
28	128	1024	0.5	0.5 S	1	0.25 S	2048	2.125 IND
90⁺	128	512	0.5	0.5 S	1	0.25 S	2	0.12 S
40 A	128	512	256	1 ADD	512	1.25 IND	512	1.125 IND
204	128	1024	128	0.6 AD	512	0.75 AD	1024	1.125 IND
B1	128	1024	256	0.75 Add	256	0.5 S	256	0.4 S
32 A	128	1024	256	0.75 AD	256	0.5 S	256	0.4 S
45 A	128	8	2	0.75 AD	4	0.75 AD	2	0.37 S
43 A	128	1024	128	0.62 AD	512	0.75 AD	1024	1.1 IND
100	128	512	2	0.5 S	16	0.28 S	32	0.18 S
46 A	128	1024	32	0.5 S	512	0.75 AD	256	0.4 S
M	128	1024	32	0.5 S	512	0.75 ADD	256	0.4 S
4A	128	1024	2	0.5 S	2	0.25 S	4	0.12 S
F	128	1024	32	0.5 S	512	0.75 ADD	256	0.4 S
67 A	128	1024	1024	1.5 IND	1024	1.25 IND	4	0.12 S
202	128	1024	512	1 AD	1024	1.25 IND	1024	1.125 IND
90	128	1024	1024	1.5 IND	1024	1.25 IND	1024	1.125 IND
89 +	128	1024	1024	1.5 IND	2048	2.25 IND	2048	2.125 IND
Z	128	1024	512	1 Ad	1024	1.25 IND	1024	1.125 IND
11A	128	1024	2	0.5 S	2	0.25 S	4	0.12 S
89	128	1024	16	0.51 S	1024	1.25 IND	1024	1.125 IND
71 A	128	256	8	0.53 S	512	2.25 IND	1024	4.12 ANT
93 +	128	1024	512	1 AD	512	0.75 AD	4	0.12 S
A	128	512	32	0.56 ADD	64	0.37 S	512	1.125 IND
300	128	512	0.5	0.5 S	1	0.25 S	2	0.128 S
28 A	128	16	2	0.625 AD	16	1.25 IND	0.5	0.15 S

S Synergism, ADD ADDITIVE, NO NO difference and ANTA Antagonism, FICI Fractional inhibitory concentration index, MIC Minimum inhibitory concentration index, Azt Azithromycin

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ISSN: 1471-2180

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