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Fig. 6 | BMC Microbiology

Fig. 6

From: Bifidobacterium longum SX-1326 ameliorates gastrointestinal toxicity after irinotecan chemotherapy via modulating the P53 signaling pathway and brain-gut axis

Fig. 6

Diagram of the potential mechanism of B. longum SX-1326 for adjuvant treatment of CRC and amelioration of post-chemotherapy side effects. In AOM and DSS-induced CRC mouse models, B. longum SX-1326 was able to enhance the expression of pro-apoptotic proteins to assist in the treatment of CRC, regulate the release of neurotransmitters, such as 5-HT, through the GBA to improve nausea and vomiting, and restore the diversity of the intestinal flora to alleviate intestinal inflammation. AOM, Azoxymethane; DSS, Dextran Sulfate Sodium Salt

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BMC Microbiology

ISSN: 1471-2180

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