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Fig. 3 | BMC Microbiology

Fig. 3

From: Bifidobacterium longum SX-1326 ameliorates gastrointestinal toxicity after irinotecan chemotherapy via modulating the P53 signaling pathway and brain-gut axis

Fig. 3

B. longum SX-1326 inhibits nausea and vomiting caused by chemotherapy drugs by modulating neurotransmitters such as SP and 5-HT in the gut-brain axis. A The kaolin weight to total feed intake of mice in each group; B Expression of FOS protein in AP region of brain tissue by immunohistochemistry (400 ×); C ELISA detects the expression of 5-HT in colon tissue; D RT-qPCR detects SP expression in colon tissue; E ELISA detection of 5-HT expression in brain tissue; F RT-qPCR to detect SP expression in brain tissues; G Detection of expression of 5-HT3R and NK-1R in AP region of brain tissue by IHC staining (400 ×). Experimental group: C: normal control group; M: colorectal cancer model group; B: Bifidobacterium longum SX-1326 group; I: Irinotecan chemotherapy group; U: Bifidobacterium longum SX-1326 plus irinotecan dosing group. Data are expressed as mean ± SD, *p < 0.05, **p < 0.01

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BMC Microbiology

ISSN: 1471-2180

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