Fig. 2
From: Rapid intestinal and systemic metabolic reprogramming in an immunosuppressed environment
Short-term drug effect on metabolome. Clustering of A) luminal metabolites and B) serum metabolites using sparse Partial Least Squares Discriminant Analysis (sPLS-DA) to demonstrate metabolic phenotypes due to drug treatments. Volcano plot combines results from fold change (FC) analysis to show significantly increased metabolites after 2-day tacrolimus treatment in C) lumen or D) serum. A metabolite is shown if FC is > 2 and p value is < 0.05 based on 2-sample t-test. Original metabolite measurement without normalization was used in FC analysis