Table 1 Amyloidogenic ‘hot-spot’ regions predicted by AGGRESCAN and TANGO. Common regions are denoted with blue

AGGRESCAN

Amyloidogenic regions

Sequence range

Region

Secondary structure element

YRYYT

46–50

HS1

α1-helix

KFRGIKIQVLL

72–82

HS2

First β-turn

GLDVFFVQ

97–104

HS3

β4-sheet

IFYTVGGV

112–119

HS4

β6-sheet

YYIKKE

151–156

HS5

Loop between β8-sheet and β9-sheet

EKYGLYK

173–179

HS6

end of α2-helix

LKFKYMGEV

205–213

HS7

α 3-helix

TANGO

VFFVQEK

100–106

HS8

β4sheet

IFYTVGGVIQ

112–121

HS9

β6-sheet

ILNIS

133–137

HS10

β7-sheet

FKYMGEVI

207–214

HS11

α3-helix and extended up to β12-sheet