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Table 4 Differential abundance of metabolites between the Fb and Fa groups

From: Multi-omics analysis of fecal microbiota transplantation’s impact on functional constipation and comorbid depression and anxiety

Compound name

Fb_Mean, (nmol/L)

Fa_Mean, (nmol/L)

VIP

P-Value

FOLD CHANGE(Fa_mean/Fb_mean)

5-HIAA

47.1935

31.8578

1.4691

0.2977

1.4814

5-HT

368.1041

26.9618

2.5908

0.0149

13.6528

5-HTP

1.9781

1.7923

1.1642

0.9112

1.1037

Ach

539.4731

622.3338

1.0378

0.6755

0.8669

Ala

112548.3949

112959.6761

0.0989

0.9766

0.9964

Arg

12241.0651

13051.2310

0.3198

0.7692

0.9379

Asn

13996.2638

13378.8519

0.6424

0.7094

1.0461

Asp

7188.5534

5327.2456

1.4999

0.2622

1.3494

BAla

905.6876

926.7793

0.0267

0.9061

0.9772

Cys

1308.2768

1587.2374

1.0659

0.5063

0.8242

DA

0.8483

0.8989

0.1708

0.9577

0.9437

DOPAC

12.1566

14.5369

0.9479

0.5418

0.8363

E

6.8521

7.4191

0.5899

0.6703

0.9236

GABA

89.3689

57.5046

1.8181

0.1421

1.5541

GSH

11.2101

3.0888

0.9312

0.3138

3.6293

Gln

112169.8325

114443.4843

0.0226

0.8462

0.9801

Glu

25710.4781

19149.0749

1.3104

0.3507

1.3426

Gly

147517.2019

145217.4144

0.1302

0.9482

1.0158

HVA

6.6168

8.4081

1.1448

0.3735

0.7869

His

29495.5926

31862.7373

0.5170

0.6717

0.9257

Hist

8.4298

9.2744

0.5340

0.6973

0.9089

Kyn

1567.6608

1787.1590

1.3495

0.2212

0.8772

LDOPA

4000.6248

3349.2705

0.5745

0.6931

1.1945

Leu

53691.8125

57996.6485

0.5609

0.5565

0.9258

Lys

27014.8680

26095.7985

0.4207

0.7705

1.0352

Met

11079.1633

12182.5056

0.6242

0.5054

0.9094

NE

7.6155

6.6504

1.5056

0.2156

1.1451

OA

275.4676

344.4639

1.8195

0.1238

0.7997

Orn

11886.2324

12547.9328

0.4288

0.7251

0.9473

Phe

29328.8464

31862.5601

0.4569

0.6538

0.9205

Put

54.9230

79.2411

1.3676

0.2611

0.6931

Ser

23610.6845

22082.6486

1.2432

0.3878

1.0692

Spd

51.4018

36.0744

0.0080

0.5506

1.4249

Spm

1.8376

0.3450

0.0203

0.2532

5.3264

Thr

16967.4760

14281.2878

1.1023

0.2888

1.1881

Trp

28470.6713

30762.5075

0.6639

0.6584

0.9255

TrpA

0.2438

0.2278

0.1484

0.9545

1.0703

Tyr

14325.2015

16764.0158

1.2463

0.3065

0.8545

TyrA

1.3762

1.6511

0.3996

0.8319

0.8335

Val

68949.8420

73676.5301

0.4762

0.6963

0.9358

Melatonin

0.1180

0.0191

0.8390

0.4243

6.1902

  1. 5-Hydroxyindoleacetic acid: 5-HIAA, Serotonin: 5-HT, 5-Hydroxytryptophan: 5-HTP, Acetylcholine: Ach, Alanine: Ala, Arginine: Arg, Asparagine: Asn, Aspartate: Asp, β-alanine: BALa, Cysteine: Cys, 3-Hydroxytyramine hydrochloride : DA, 3,4-Dihydroxyphenylacetic acid: DOPAC, Epinephrine: E, 4-Aminobutyric acid: GABA, Glutathione: GSH, Glutamine: Gln, Glutamic acid: Glu, Glycine: Gly, Homovanillic acid: HVA, Histidine: His, Histamine: Hist, Kynurenine: Kyn, 3,4-Dihydroxyphenylalanine: LDOPA, Leucine: Leu, Lysine: Lys, Methionine: Met, Norepinephrine: NE, Octopamine: OA, Ornithine : Orn, Phenylalanine: Phe, Putrescine: Put, Serine: Ser, Spermidine: Spd, Spermine: Spm, Threonine: Thr, Tryptophan: Trp, Tryptamine: TrpA, Tyrosine: Tyr, Tyramine: TyrA, Valine: Val
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BMC Microbiology

ISSN: 1471-2180

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