Fig. 8

Alpha diversity and abundance of OTU of intestinal bacteria. A Alpha diversity shown by Shannon index estimated for each group: NC: negative control (n = 6); CEC15: healthy CEC15-treated (n = 7); EcN: healthy EcN-treated (n = 7); MUC: mucositis control (n = 4); CEC/MUC: mucositis CEC15-treated (n = 5); EcN/MUC: mucositis EcN-treated (n = 5). B Relative abundance of intestinal microbiota at the phylum level among the groups. C Heatmap analysis of the bacterial genus distribution among the 34 samples based on hierarchical clustering. One-way ANOVA and Bonferroni multiple comparisons test. Different letters indicate significative differences, p value < 0.05