Table 3 Molecular characteristics of N. meningiditis carriage isolates recovered in Lithuania (December 2021–February 2023), and estimation of 4CMenB and MenB-Fhbp vaccine coverage
No of isolates | Genogroup | ST | CC | FetA-VR | PorA | Peptide variant | Vaccine coverage | |||
|---|---|---|---|---|---|---|---|---|---|---|
VR1 | VR2 | fHbp | NHBA | 4CMenB | MenB-Fhbp | |||||
1 | B | 213 | 213 | F5-5 | 22 | 36 | 45 | 18 | not covered by fHbp + NHBA | covered |
2 | B | 10864 | 269 | F1-5 | 19 | 15−1 | 13 | 10 | insufficient data | cross-reactive |
1 | B | 17028 | 4821 | F3-36 | 12−6 | 13–22 | 16 | 669 | insufficient data | cross-reactive |
1 | cnl | 53 | 53 | F1-2 | 7 | 30 | 102 | 58 | insufficient data | insufficient data |
1 | cnl | 198 | 198 | F5-5 | 18 | − | − | 10 | NHBA cross-reactive | not covered |
1 | cnl | 823 | 198 | − | 18 | 25−14 | 4 | 10 | fHbp + NHBA cross-reactive | cross-reactive |
1 | cnl | 1136 | 1136 | F5-8 | 18−4 | 25 | − | 145 | insufficient data | not covered |
1 | cnl | 6096 | 1136 | F5-8 | 18−4 | 25 | − | 145 | insufficient data | not covered |
1 | cnl | 11563 | 11563 | F3-8 | 21−2 | 23 | 18 | 1524 | insufficient data | insufficient data |
1 | cnl | 17519 | UA | F3-7 | 17−1 | 23−7 | 21 | NA | not covered | cross-reactive |
1 | NG | 16804 | 1157 | F5-36 | 21−7 | 16 | 13 | 114 | insufficient data | cross-reactive |
1 | NG | 5953 | UA | F5-7 | 18−1 | − | 22 | 601 | insufficient data | insufficient data |
1 | Y | 865 | 865 | F1-6 | 7−1 | 1 | 19 | 19 | insufficient data | insufficient data |
1 | Y | 16644 | UA | F1-66 | 7−1 | 1 | 321 | 9 | insufficient data | insufficient data |