Fig. 4From: Increased bacterial taxonomic and functional diversity is associated with impaired rotavirus vaccine immunogenicity in infants from India and MalawiVolcano plots of feature enrichment by oral rotavirus vaccine seroconversion. Italicised numbers display the number of features with a prevalence difference of < 0 (left of vertical dotted line) or ≥ 0 (right of vertical dotted line), highlighting features enriched in non-seroconverters and seroconverters, respectively. The horizontal dotted line indicates an FDR p value of 0.2. The significance tests below the italicised numbers indicate the results of a Wilcoxon rank-sum test assessing skew in the distribution of associations (with a null hypothesis that negative and positive associations occur with equal frequency). Analyses for Indian infants are reported for the overall cohort and stratified by neonatal wild-type rotavirus exposure. EC, enzyme commission; FDR, false discovery rate; IND, India; MLW, Malawi; neo + , infected with rotavirus neonatally (defined by detection of rotavirus shedding in week of life 1 or baseline seropositivity); neo-, uninfected with rotavirus neonatally; sero + , seroconverters; sero-, non-seroconverters; ** p < 0.005; *** p < 0.0005Back to article page