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Table 5 Resistance gene profiles in CoNS species and M. sciuri recovered from DFUs and Healthy skin (n = 26)

From: Whole genome sequencing and pan-genome analysis of Staphylococcus/Mammaliicoccus spp. isolated from diabetic foot ulcers and contralateral healthy skin of Algerian patients

 

M.sciuri

(n = 1) n(%)

S.caprae

(n = 2) n(%)

S.epidermidis (n = 10) n(%)

S.haemolyticus (n = 8) n(%)

S.hominis

(n = 1) n(%)

S.saprophyticus (n = 1) n(%)

S.simulans

(n = 3) n(%)

Total

(n = 26) n(%)

*p-value

Resistance genes

 

β-lactams

         

blaZ

0(0)

2(100)

10(100)

8(100)

1(100)

0(0)

0(0)

21(80.8)

< 0.001

blaI

0(0)

2(100)

1(10)

2(25)

0(0)

0(0)

0(0)

5(19.2)

0.103

blaR1

0(0)

1(50)

1(10)

2(25)

0(0)

0(0)

0(0)

4(15.4)

0.714

mecA

1(100)

0(0)

9(90)

8(100)

1(100)

0(0)

0(0)

19(73.1)

0.002

mecA1

1(100)

0(0)

0(0)

0(0)

0(0)

0(0)

0(0)

1(3.8)

< 0.001

mecI

1(100)

0(0)

1(10)

0(0)

0(0)

0(0)

0(0)

2(7.7)

0.038

mecR1

1(100)

0(0)

1(10)

0(0)

0(0)

0(0)

0(0)

2(7.7)

0.038

Aminoglycoside

         

aac(6’)- aph(2’’)

0(0)

0(0)

0(0)

5(62.5)

0(0)

0(0)

0(0)

5(19.2)

0.030

aac(6’)-Ie/aph(2’’)-Ia

1(100)

0(0)

0(0)

2(25)

0(0)

0(0)

0(0)

3(11.5)

0.079

aph(3’)-III

0(0)

0(0)

0(0)

4(50)

0(0)

0(0)

0(0)

4(15.4)

0.100

aph(3’)-IIIa

0(0)

0(0)

0(0)

2(25)

0(0)

0(0)

0(0)

2(7.7)

0.560

sat4

0(0)

0(0)

0(0)

2(25)

0(0)

0(0)

0(0)

2(7.7)

0.560

Streptogramin

         

vat(B)

0(0)

0(0)

0(0)

1(12.5)

0(0)

0(0)

0(0)

1(3.8)

0.886

vat(C)

0(0)

0(0)

0(0)

1(12.5)

0(0)

0(0)

0(0)

1(3.8)

0.886

vgb(B)

0(0)

0(0)

0(0)

1(12.5)

0(0)

0(0)

0(0)

1(3.8)

0.886

Macrolides

         

mph (C)

0(0)

0(0)

2(20)

8(100)

0(0)

0(0)

0(0)

10(38.5)

0.004

msr(A)

0(0)

0(0)

2(20)

8(100)

1(100)

0(0)

0(0)

11(42.3)

0.003

ermC

0(0)

0(0)

1(10)

5(62.5)

0(0)

0(0)

0(0)

6(23.1)

0.110

vga(A)

0(0)

0(0)

0(0)

1(12.5)

0(0)

0(0)

3(100)

4(15.4)

0.004

vga(B)

0(0)

0(0)

0(0)

1(12.5)

0(0)

0(0)

0(0)

1(3.8)

0.886

vga(A)LC

0(0)

0(0)

0(0)

1(12.5)

0(0)

0(0)

0(0)

1(3.8)

0.886

sal(A)

1(100)

0(0)

0(0)

0(0)

0(0)

0(0)

0(0)

1(3.8)

< 0.001

Tetracycline

         

tet(L)

0(0)

0(0)

0(0)

1(12.5)

0(0)

0(0)

0(0)

1(3.8)

0.886

tet(K)

0(0)

7(70)

0(0)

0(0)

0(0)

0(0)

0(0)

7(26.9)

0.018

Fusidic acid

         

fusB

0(0)

1(50)

9(90)

3(37.5)

0(0)

0(0)

0(0)

13(50)

0.045

fusC

0(0)

0(0)

1(10)

1(12.5)

0(0)

0(0)

0(0)

2(7.7)

0.986

Trimethoprim-sulfamethoxazole

   

dfrG

0(0)

0(0)

0(0)

5(62.5)

0(0)

0(0)

0(0)

5(19.2)

0.030

dfrS1

0(0)

0(0)

1(10)

0(0)

0(0)

0(0)

0(0)

1(3.8)

0.948

Fosfomycin

         

fosB

0(0)

0(0)

10(100)

0(0)

0(0)

0(0)

0(0)

10(38.5)

< 0.001

Streptomycin

         

str

0(0)

0(0)

0(0)

1(12.5)

0(0)

0(0)

0(0)

1(3.8)

0.886

kanamycin and neomycin

 

aadD

0(0)

0(0)

0(0)

1(12.5)

0(0)

0(0)

0(0)

1(3.8)

0.886

Quaternary ammonium compounds

         

qacB

0(0)

0(0)

0(0)

1(12.5)

0(0)

0(0)

0(0)

1(3.8)

0.886

  1. *Chi-squared test was used to calculate p-values for describing the association between genes and species, p-values < 0.05 were considered statistically significant
  2. Values are numbers and percentages in brackets
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BMC Microbiology

ISSN: 1471-2180

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