Fig. 1

EB211 and EB279 caused no toxicity to the kidneys and liver of mice. No noticeable histopathological changes were observed in the kidneys and liver of mice injected intraperitoneally twice daily with EB211 (12 mg/kg), EB279 (12 mg/kg), or a cocktail of the two scFvs (CKT; 6 mg/kg of each) for 72 h, similar to mice injected intraperitoneally twice daily with colistimethate sodium (CMS; 30 mg/kg) or normal saline (NS). Green arrowheads: sinusoids, V: central venules, Yellow arrowheads: hepatocytes, Yellow arrows: renal tubule and renal corpuscle