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Table 3 List of DEGs in Silversol exposed P. aeruginosa satisfying the dual criteria of log fold-changeā€‰ā‰„ā€‰2 and FDRā€‰ā‰¤ā€‰0.05

From: Sub-lethal concentration of a colloidal nanosilver formulation (SilversolĀ®) triggers dysregulation of iron homeostasis and nitrogen metabolism in multidrug resistant Pseudomonas aeruginosa

Sr. No.

Gene ID

Gene Symbol

Codes for

Log FC

FDR

Up- or down-regulation

Node degree

1

PA0522

NA

hypothetical protein

4.9

5.87E-06

ā†‘

6

2

PA2691

NA

conserved hypothetical protein

4.2

5.10284E-05

ā†‘

0

3

PA2689

NA

hypothetical protein

4.02

0.0002

ā†‘

0

4

PA0521

NA

probable cytochrome c oxidase subunit

3.91

0.0002

ā†‘

10

5

PA4623

NA

hypothetical protein

3.5

0.001

ā†“

2

6

PA3237

NA

hypothetical protein

3.47

0.001

ā†“

0

7

PA0524

norB

nitric-oxide reductase subunit B

3.41

0.001

ā†‘

13

8

PA3877

narK1

nitrite extrusion protein 1

3.27

0.003

ā†‘

9

9

PA3872

narI

respiratory nitrate reductase gamma chain

3.21

0.01

ā†‘

7

10

PA2868

NA

hypothetical protein

3.16

0.01

ā†“

0

11

PA3871

NA

probable peptidyl-prolyl cis-trans isomerase, PpiC-type

3.01

0.02

ā†‘

4

12

PA0532

NA

hypothetical protein

2.99

0.01

ā†“

0

13

PA3395

nosY

NosY protein

2.98

0.02

ā†‘

8

14

PA0520

nirQ

regulatory protein NirQ

2.9

0.02

ā†‘

11

15

PA3873

narJ

respiratory nitrate reductase delta chain

2.89

0.04

ā†‘

5

16

PA0516

nirF

heme d1 biosynthesis protein NirF

2.84

0.02

ā†‘

12

17

PA2663

ppyR

psl and pyoverdine operon regulator, PpyR

2.82

0.05

ā†‘

0

18

PA0518

nirM

cytochrome c-551 precursor

2.82

0.03

ā†‘

8

19

PA0519

nirS

nitrite reductase precursor

2.74

0.03

ā†‘

14

20

PA0525

NA

probable dinitrification protein NorD

2.73

0.03

ā†‘

10

21

PA3392

nosZ

nitrous-oxide reductase precursor

2.72

0.03

ā†‘

10

22

PA4354

NA

conserved hypothetical protein

2.7

0.04

ā†“

2

23

PA3393

nosD

NosD protein

2.6

0.05

ā†‘

8

24

PA3407

hasAp

heme acquisition protein HasAp

2.59

0.05

ā†‘

0

25

PA3874

narH

respiratory nitrate reductase beta chain

2.58

0.05

ā†‘

7

26

PA1942

NA

hypothetical protein

2.57

0.05

ā†“

2

  1. Genes are arranged in decreasing order of Fold Change. Databases consulted for gene functions were: NCBI gene database (https://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/nuccore/NC_002516); KEGG (Kyoto Encyclopaedia of Genes and Genomes: https://www.genome.jp/kegg/); Uniprot (https://www.uniprot.org/). NA: not available