Association between oral microbial dysbiosis and poor functional outcomes in stroke-associated pneumonia patients

BMC Microbiology

Table 3 Cox regression analysis of risk factors associated with SAP and the relative abundance of specific taxa

Risk factor	Univariate analysis		Multivariate analysis*		Multivariate analysis^#
Risk factor	HR(95% CI)	P value	Model 1 aHR(95% CI)	P value	Model 2 aHR(95% CI)	P value
Protective bacteria
*p__Firmicutes*	0.016(0.002–0.160)	<0.001	NA	NA	NA	NA
*c__Bacilli*	0.090(0.028–0.290)	<0.001	0.190(0.042–0.864)	0.032	0.139(0.035–0.552)	0.005
*o__Lactobacillales*	0.095(0.031–0.292)	<0.001	0.183(0.044–0.766)	0.020	0.154(0.043–0.557)	0.004
*f__Streptococcaceae*	0.125(0.043–0.367)	<0.001	0.223(0.063–0.794)	0.021	0.184(0.056–0.602)	0.005
*g__Streptococcus*	0.125(0.043–0.367)	<0.001	0.223(0.063–0.794)	0.021	0.184(0.056–0.602)	0.005
Hazardous bacteria
*p__Bacteroidota*	4.732(1.434–15.618)	0.011	NA	NA	NA	NA
*c__Bacteroidia*	4.735(1.435–15.636)	0.011	NA	NA	NA	NA
*o__Bacteroidales*	4.557(1.492–13.913)	0.008	NA	NA	NA	NA
*f__Prevotellaceae*	4.147(1.559–11.032)	0.004	NA	NA	NA	NA
*g__Prevotella*	4.508(1.781–11.778)	0.002	NA	NA	3.224(1.147–9.063)	0.026
F/B	0.254(0.107–0.601)	0.002	NA	NA	NA	NA
S/P	0.345(0.202–0.590)	<0.001	NA	NA	0.424(0.231–0.776)	0.005

*adjusted by age, initial NIHSS score, enteral nutrition, atrial fibrillation, dysphagia, and NLR(neutrophil to lymphocyte ratio)
#adjusted by A2DS2 score
F/B Firmicute/Bacteroidota (F/B) ratio; S/P Streptococcus/Prevotella (S/P) ratio

ISSN: 1471-2180