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Table 4 Effects of combinations on 10 K. pneumoniae strains in biofilm state

From: In Vitro antibiotic combinations of Colistin, Meropenem, Amikacin, and Amoxicillin/clavulanate against multidrug-resistant Klebsiella pneumonia isolated from patients with ventilator-associated pneumonia

Clinical

Isolate

COL / MEM

COL / AMC

MEM / AMC

AK / COL

AK / MEM

AK / AMC

 

MBEC

FICI

MBEC

FICI

MBEC

FICI

MBEC

FICI

MBEC

FICI

MBEC

FICI

 

K.1

8/4

0.53 (I)

8/(2048/1024)

0.75 (I)

32/(4096/2048)

0.75 (I)

32/4

0.50 (S)

32/64

0.75 (I)

32/(4096/2048)

0.75 (I)

 

K.2

4/32

0.38 (S)

2/(512/256)

0.19 (S)

64/(512/256)

0.31 (S)

1024/8

0.75 (I)

1024/64

0.50 (S)

1024/(256/128)

0.28 (S)

 

K.3

8/32

0.50 (S)

8/(128/64)

0.27 (S)

32/(256/128)

0.28 (S)

1024/16

1.00 (I)

1024/64

1.00 (I)

1024/(4096/2048)

1.00 (I)

 

K.4

4/128

0.75 (I)

4/(256/128)

0.28 (S)

16/(1024/512)

0.19 (S)

128/2

0.25 (S)

512/64

0.75 (I)

512/(1024/512)

0.63 (I)

 

K.5

4/256

0.31 (S)

1/(2048/1024)

0.31 (S)

256/(4096/2048)

0.56 (I)

2048/4

0.50 (S)

4096/2048

1.00 (I)

2048/(2048/1024)

0.50 (S)

 

K.6

4/4

0.75 (I)

4/(256/128)

0.53 (I)

8/(2048/1024)

0.75 (I)

8/2

0.38 (S)

8/2

0.25 (S)

32/(2048/1024)

0.75 (I)

 

K.7

64/256

0.75 (I)

64/(4096/2048)

0.75 (I)

256/(256/128)

0.53 (I)

256/128

0.75 (I)

512/128

0.75 (I)

64/(512/256)

0.13 (S)

 

K.8

32/16

0.31 (S)

32/(4096/2048)

0.75 (I)

32/(512/256)

0.19 (S)

128/32

0.31 (S)

256/32

0.25 (S)

128/(512/256)

0.13 (S)

 

K.9

8/64

1.13 (I)

16/(128/64)

0.27 (S)

64/(2048/1024)

1.25 (I)

32/16

0.31 (S)

128/32

0.75 (I)

256/(256/128)

0.53 (I)

 

K.10

16/256

0.38 (S)

32/(1024/512)

0.63 (I)

256/(4096/2048)

0.63 (I)

256/16

0.50 (S)

256/1024

0.75 (I)

256/(4096/2048)

0.75 (I)

 
  1. COL: colistin; MEM: meropenem; AMC: amoxicillin clavulanate; AK: amikacin. MBEC, minimum biofilm eradication concentration that expressed in mg/L. S, synergy; I, indifferent.