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Table 4 Anticancer activity of HA against three cancer cell lines

From: Hyaluronic acid production by Klebsiella pneumoniae strain H15 (OP354286) under different fermentation conditions

HA conc.

(µg mL-1)

Cell viability (%)

MCF-7

(breast)

HepG-2

(liver)

HCT

(colon)

500

57.40± 1.96e

63.33±2.41d

27.83±6.93d

250

64.69± 1.21d

64.59±1.66d

58.00±2.63c

125

74.58± 5.21cd

72.52±1.85c

75.33±3.74b

62.5

74.69± 7.25c

73.19±2.11c

77.83±4.11b

31.25

76.88± 3.96c

76.67±3.33bc

77.83±3.62b

15.63

80.52± 5.24bc

81.85±1.17b

78.33±2.22b

7.81

89.69± 1.62b

93.78±2.86a

79.00±4.62b

3.91

95.10 ±2.82ab

99.63±3.10a

79.33±3.85b

1.95

98.33 ±1.66a

100±5.23a

84.17±2.71b

0.98

99.48 ±2.17a

100±3.62a

98.33±2.46a

0.49

100±1.29a

100±4.22a

100±3.82a

0.24

100±2.33a

100±2.63a

100±6.23a

IC50 (µg mL-1)

1538.06

1209.21

273.40

  1. Means± SD in the same column with different superscripts are significantly different (LSD test, P ≤ 0.05)
  2. Different letters on the bars (a, b, c, d, e) indicate significant differences between the data points