Table 1 Promising methods for eradicating Pseudomonas aeruginosa infections stages
Strategies/combinations | Targets | Results | References |
|---|---|---|---|
Octenidine dihydrochloride-based antiseptic (OCT) and rotating magnetic field (RMF) of two frequencies, 5 and 50 Hz | Biofilms | Biofilm destruction | [61] |
Graphene oxide-lignin/silk fibroin/ZnO nanobiocomposite | Biofilms | Prevented biofilm formation | [62] |
Combined colistin, AgNPs and decellularized human amniotic membrane (dHAM) | P. aeruginosa from burn wounds | Faster wound reduction, presence of considerable fibrosis, complete epithelial reorganization and absence of bacteria on day 21 | [63] |
Chimeric bacteriocin S5-PmnH | Abolished strain resistance, reduced bacterial numbers, eradicated cytotoxic strain and prevented acute disease | [64] | |
Anamorphous coatings modified with Cu2O nanofibers (coating PC) | Bacterial adhesion | Cytoplasmic outflow and cell membrane destruction, killing effect of Cu+ ions | [65] |
C16-terpene dilactone (CJ-14445) from Neofusicoccum luteum | Bacteria colonies | Antibacterial activity | [66] |
Fluorothiazinon | Type III Secretion System (T3SS) | Suppressed the T3SS without affecting bacterial growth | [67] |
Synthetic smectite clay minerals and Fe-sulfide microspheres | Bacteria cells | Maintainance of Fe2+ solubility and reactive oxygen species production, bacteria killing | [68] |
Essential oil from Elsholtzia beddomei C. B. Clarke ex Hook. f | Bacterial growth | Antibacterial inhibitory effects | [69] |
Iodine-loaded polymers I2@NRPOP-1 and I2@NRPOP-2 | Bacterial growth | Growth inhibition | [70] |
Zinc oxide nanoparticles (ZnO NPs) | Growth inhibition Disruption of cytoplasmic membrane Generation of reactive oxygen species (ROS) | [71] | |
Parkia timoriana (Yongchak/Zawngtah) extract | Bacterial growth | Growth inhibition | [72] |
K3[Ga(ox)3]·3H2O and K4[Ga2 (ox)4 (μ-OH)2]·2H2O | Bacterial growth | Growth inhibition | [73] |
Metallic nanoparticles (MNPs) dip-coating | Bacteria cells | Significant bacterial killing behavior | [74] |
Biosynthetic silver nanoparticles (AgNPs) based on Gmelina arborea logging residue (GA-AgNPs) | Biofilms and Bacterial growth | Antibacterial, antibiofilm, antioxidant, and wound healing properties, non-toxicity to mammalian cells | [75] |
Intraocular implant, MXF-HA, combining hyaluronic acid (HA) and moxifloxacin (MXF) and settled in the eye | Bacterial growth | Growth inhibition | [76] |
N-(2-hydroxyphenyl)-2-phenazinamine from marine actinomycete Nocardiopsis exhalans | Biofilms | Excellent biofilm inhibitory activity | [77] |