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Fig. 5 | BMC Microbiology

Fig. 5

From: Proteomic response of Escherichia coli to a membrane lytic and iron chelating truncated Amaranthus tricolor defensin

Fig. 5

Decoration of lipid A in the outer membrane with L-Ara4N moieties is regulated by cross talk between two-component regulatory systems. Membrane lytic AMPs initiates the phosphorylation (orange) of PhoP by PhoQ activating translation of pmrD. PmrD protects PmrA (phosphorylated by PmrB) from dephosphorylation. Phosphorylated PmrA activates translation of the arn gene cluster. Proteins produced by the arn gene cluster synthesize L-Ara4N moieties (green) which are transferred by ArnT to lipid A (yellow). Modified lipopolysaccharides (LPS) are transported to outer membrane decreasing electrostatic interactions and inhibiting membrane lysis. Color scheme indicates proteins or protein products of genes whose abundance increased (red) or did not change (purple) after treatment with Atr-DEF2(G39-G54). Genes whose proteins products were not detected in either conditions are grey

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BMC Microbiology

ISSN: 1471-2180

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