T cell markers | Â | HIV ART (+) | P-value | |
---|---|---|---|---|
Health Control | Immune Responders (IR) | Immune Non-responders (INR) | ||
Nadir CD4+ T cells (mean ± SD) | NA | 309.89 ± 128.81 | 95.23 ± 108.92 | < 0.0001 |
Current CD4 + T cells (mean ± SD) | NA | 608.30 ± 158.25 | 230.5 ± 87.50 | < 0.0001 |
Current CD4+/CD8+ T-cell ratio | NA | 0.8 ± 0.36 | 0.35 ± 0.20 | < 0.0001 |
HIV RNA | NA | ND | ND | Â |
%CD4 + HLADR+CD38+ | NA | 7.72 ± 4.30 | 10.30 ± 10.45 | NS |
%CD4 + CD25+ | NA | 1.26 ± 0.99 | 1.09 ± 1.04 | NS |
%CD4 + CD57+ | NA | 2.57 ± 1.92 | 2.43 ± 3.30 | NS |
%CD8 + HLADR+CD38+ | NA | 20.68 ± 11.35 | 23 ± 12.39 | NS |
%CD8 + CD57+ | NA | 14.36 ± 7.11 | 23.98 ± 12.30 | 0.001 |
Cytokines | ||||
 IL-2(pg/mL, mean ± SD) | 9.47 ± 6.79 | 120.96 ± 113.96 | 153.81 ± 118.79 | < 0.0001 |
 IL-4(pg/mL, mean ± SD) | 13.49 ± 31.01 | 34.52 ± 43.30 | 32.51 ± 31.17 | 0.009 |
 IL-6(pg/mL, mean ± SD) | 8.39 ± 12.57 | 126.90 ± 95.33 | 130.82 ± 60.62 | < 0.0001 |
 IL-9(pg/mL, mean ± SD) | 3.68 ± 6.20 | 94.00 ± 78.07 | 96.57 ± 48.71 | < 0.0001 |
 IL10(pg/mL, mean ± SD) | 2.48 ± 2.35 | 44.69 ± 37.66 | 51.32 ± 31.65 | < 0.0001 |
 IL-13(pg/mL, mean ± SD) | 85.45 ± 65.02 | 96.76 ± 71.54 | 82.94 ± 62.96 | NS |
 IL-17A (pg/mL, mean ± SD) | 26.22 ± 52.89 | 133.41 ± 161.61 | 94.80 ± 83.84 | < 0.0001 |
 IL-17F (pg/mL, mean ± SD) | 5.45 ± 5.68 | 19.15 ± 19.48 | 20.59 ± 20.34 | < 0.0001 |
 IL-21(pg/mL, mean ± SD) | 41.33 ± 48.87 | 104.43 ± 88.11 | 93.84 ± 56.89 | 0.002 |
 IL-22(pg/mL, mean ± SD) | 153.98 ± 97.15 | 291.60 ± 176.36 | 293.10 ± 125.37 | 0.001 |
 IFN-γ (pg/mL, mean ± SD) | 12.55 ± 29.52 | 81.57 ± 84.50 | 69.36 ± 83.42 | < 0.0001 |
 TNF-α (pg/mL, mean ± SD) | 8.39 ± 15.57 | 38.86 ± 44.19 | 32.22 ± 26.47 | < 0.0001 |
 LPS (pg/mL, mean ± SD) | 24.22 ± 18.88 | 76.55 ± 40.05 | 104.98 ± 56.15 | < 0.0001b |
 sCD14(pg/mL, mean ± SD) | 1583.60 ± 292.80 | 2480.42 ± 999.88 | 2142.65 ± 496.53 | < 0.0001 |
Pyrosequencing data | ||||
 Sobs indexa | 194.11 ± 47.45 | 116.89 ± 39.71 | 118.11 ± 46.96 | < 0.0001 |
 Shannon indexa | 3.14 ± 0.53 | 2.47 ± 0.54 | 2.44 ± 0.56 | < 0.0001 |
 Simpson indexa | 0.12 ± 0.09 | 0.19 ± 0.11 | 0.19 ± 0.13 | < 0.0001 |
 ACEa | 223.97 ± 53.59 | 147.26 ± 39.98 | 148.41 ± 49.99 | < 0.0001 |
 Chao 1 indexa | 224.29 ± 54.76 | 144.52 ± 45.25 | 145.37 ± 51.01 | < 0.0001 |
 Good’s coverage (%) a | 99.82 ± 0.04 | 99.87 ± 0.04 | 99.87 ± 0.04 | < 0.0001 |