Accessory gene regulator (agr) dysfunction was unusual in Staphylococcus aureus isolated from Chinese children

Table 6 agr mutations for non-hemolytic isolates

Strain	MLST	agr mutations	Predicted results
R85^a	59	agrC 62–63 ins t	Frameshift-truncated AgrC
R90^a	59	agrA g443a	Asp>Gly at aa 148 in AgrA
11-3^b	239	agrD a48g; agrC t884c	No aa change in agrD; Ile > Thr at aa 295 in AgrC
11-6^b	239	None	None
11-15^c	9	agrB g519a; Many mutations in agrC and agrA	No aa change in AgrB; Many aa changes in AgrC and AgrA
12-31^b	239	None	None
12-98^b	1296	agrD a7g; agrC a704c + a875g	Thr > Ala at aa 3 in AgrD; Tyr > Ser at aa 235 + Asn > Ser at aa 292 in AgrC
SA2017112^b	239	agrA t615c	No aa change in AgrA
S14^d	398	agrC c415t; agrA c263t	Pro>Ser at aa 139 in AgrC; Thr > Met at aa 88 inAgrA
S78^e	22	agrC 434–435 ins t	Frameshift-truncated AgrC

^aCompared to SA957 genome (NC_022442.1); ^bCompared to NCTC8325 genome (CP000253.1); ^cCompared to N315 genome (NC_002745.2); ^dCompared to ST398 genome (NC_017333.1); ^eCompared to H-EMRSA-15 genome (CP007659.1). ins, insertion; del, deletion; aa, amino acid; −, not applicable

ISSN: 1471-2180