Gut microbiome patterns correlate with higher postoperative complication rates after pancreatic surgery

Schmitt, Felix C. F.; Brenner, Thorsten; Uhle, Florian; Loesch, Svenja; Hackert, Thilo; Ulrich, Alexis; Hofer, Stefan; Dalpke, Alexander H.; Weigand, Markus A.; Boutin, Sébastien

doi:10.1186/s12866-019-1399-5

BMC Microbiology

Table 2 Patients’ characteristics grouped by colonisation status (non-community B vs. community B)

From: Gut microbiome patterns correlate with higher postoperative complication rates after pancreatic surgery

	Non-community B	Community B	p-value non- community B. vs. community B
Number	13	19
Age [years]	62.0 (51.0–68.0)	67.0 (58.0–75.0)	0.150
ASA status	2.0 (2.0–2.0)	3.0 (2.0–3.0)	0.070
Cardiovascular risk factors
Coronary heart disease	1 (7.7%)	2 (10.5%)	0.787
Diabetes	3 (23.1%)	5 (26.3%)	0.835
Arterial hypertension	5 (38.5%)	8 (42.1%)	0.837
Chronic renal failure	0 (0.0%)	0 (0.0%)	1.000
Primary disease
Malignant	6 (46.2%)	13 (68.4%)	0.208
IPMN	3 (23.1%)	5 (26.3%)	0.835
Chronic pancreatitis	4 (30.8%)	1 (5.2%)	0.051
Operation
Partial pancreaticoduodenectomy	0 (0.0%)	7 (36.8%)	0.013*
Pylorus-preserving pancreas head resection	5 (38.0%)	6 (31.6%)	0.687
Total pancreatectomy	2 (15.4%)	1 (5.3%)	0.335
Distal pancreatectomy	3 (23.1%)	3 (15.8%)	0.604
Tumour enucleation	3 (23.1%)	2 (10.5%)	0.337
Surgery [min]	195.0 (180.0–285.0)	315.0 (210.0–345.0)	0.273
Blood loss¹ [mL]	600.0 (200.0–1000.0)	700 (500–950)	0.630
Infusion¹ [mL]	3000.0 (2500.0–4000.0)	3000.0 (2500.0–4000.0)	0.684
Transfusion¹ [mL]	0.0 (0.0–0.0)	0.0 (0.0–0.0)	1.000
CRP² [mg/L]	73.2 (36.1–105.1)	102.7 (51.6–155.0)	0.006**
Leucocytes² [1/nL]	9.0 (7.8–9.9)	11.1 (8.4–13.8)	0.022*
Hospital stay
In total [days]	11.0 (9.0–14.0)	15.0 (11.0–36.5)	0.030*
Intermediate care unit [days]	0.0 (0.0–0.0)	0.0 (0.0–3.0)	0.439
Intensive care unit [days]	0.0 (0.0–0.0)	0.0 (0.0–1.0)	0.032*
Postoperative complications [Clavien-Dindo classification]
Total number	3 (23.1%)	14 (73.7%)	0.005**
Grade I	2 (15.4%)	2 (10.5%)	0.683
Grade II	1 (7.7%)	5 (26.3%)	0.185
Grade III³	0 (0.0%)	6 (31.6%)	0.044*
Grade IV⁴	0 (0.0%)	2 (10.5%)	0.227
Grade V	0 (0.0%)	0 (0.0%)	1.000
Outcome
Survivor 90 days	13 (100.0%)	19 (100.0%)	1.000

Data are presented as the median and interquartile range (Q1–Q3) or as count and percentage. A p-value < 0.05 was considered statistically significant and are highlighted in boldface. Concerning symbolism and higher orders of significance: p < 0.05 *, p < 0.01 **, p < 0.001 ***. ASA status, American Society of Anesthesiologists physical status classification system; IPMN, intraductal papillary mucinous neoplasm; CRP, C-reactive protein. ¹Two patients suffered from medical and surgical complications, therefore both have been allocated into the medical as well as the surgical complication group; ²total measured intraoperatively; ³postoperative observation period; ⁴includes grades IIIa and IIIb; ⁵includes grades IVaand IVb

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ISSN: 1471-2180

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