Gene-coded protein/Function | Fold Changea |
---|---|
B and T cell activation genesb | |
Cd2/Induces IFN-γ, interacts with PTPRC | + 2.9 |
Cd21 (Cr2)/B cell complement receptor | + 3.0 |
Hells/Helicase - Cell growth, DNA methylation | + 2.5 |
Hsp90aa1/AKT signal transduction pathway, protein chaperon | + 2.3 |
Il4/TH-2 cytokine (IL-4) | - 2.6 |
Il10/TH-2 cytokine (IL-10) | + 3.6 |
Il12b/TH-1 cytokine (IL-12p40) | - 2.7 |
Impdh/Cell growth | + 2.5 |
Nkx2.3/Lymphocyte cellular differentiation | + 2.3 |
Prkcd/B-cell signal transduction and apoptosis | + 2.2 |
Prlr/Prolactin receptor | + 2.1 |
Ptprc/(CD45/B220) cell growth/differentiation | + 3.0 |
Tlr1/Proinflammatory receptor for microbes | - 2.5 |
Tlr6/Proinflammatory receptor for microbes | + 2.3 |
Vav1/T and B cell activation via JNK and P38 | + 2.1 |
Wwp1/E3 ubiquitin protein ligase | + 2.4 |
Zap70/T cell receptor cofactor | - 2.4 |
Nf-κb signal transduction genesc | |
Bcl2/Anti-apoptotic signaling | - 1.1 |
Bcl2l10/Pro-apoptotic, pro-inflammatory signaling | - 1.8 |
Cflar/Pro-apoptotic signaling | - 1.2 |
Egr1/B-cell receptor signaling | - 2.1 |
Fasl/Intercellular signaling, pro-apoptotic | - 3.3 |
Fos/Intracellular signaling, pro-apoptotic | - 3.1 |
Icam1/Leukocyte movement, signaling | - 2.3 |
Iκκa (Chuk)/Pro-inflammatory activator of NF-κB | - 2.1 |
Irak2/Induces NFκB nuclear translocation | + 2.3 |
Jun/(AP-1) B-cell and T-cell receptor signaling | + 2.1 |
Mekk/(Map3k1) Pro-inflammatory | - 2.2 |
Myd88/Pro-apoptotic and inflammatory adapter | - 3.8 |
Nfkbia/Blocks NFκB nuclear translocation | - 2.1 |
Relb/NFκB cofactor activation in B-cells | - 3.0 |
Ripk1/Pro-inflammatory, apoptosis regulatory | - 1.1 |
Rnf7/IκB ubiquitination – pro-apoptotic, pro-inflammatory | - 3.8 |
Traf2/Pro-inflammatory, apoptosis regulatory | - 1.7 |
Apoptosis genesd | |
Akt1/Anti-apoptotic | - 2.1 |
Bad/Anti- apoptotic | - 2.2 |
Card10/Proinflammatory via NFκB, pro-apoptotic | - 4.3 |
Casp2/Pro-apoptotic | - 2.3 |
Casp12/Pro-apoptotic | - 2.8 |
Dad1/Possible apoptosis inhibitor | - 3.1 |
Fadd/Pro-apoptotic | - 2.2 |
Pak7/Protein kinase induces proliferation/ anti-apoptotic | - 4.2 |
Tnf/Pro-apoptotic cytokine | - 2.4 |