Table 1 Metabolic pathway-independent druggable proteins
S. No. | Gene | Protein name | Uniprot ID | Function |
|---|---|---|---|---|
1 | FN1275 | Acriflavin resistance protein B | Q8RE51 | Resistant to aminoglycosides such as amikacin, gentamycin, kanamycin, neomycin and tobromycin as well as to amphiphilic compounds. Thus, inhibiting AcrB function may lead to pathogen’s susceptibility to these antibiotics. |
2 | FN1321 | Acetoacetate metabolism regulatory protein atoC | Q8RE11 | Required for catabolism of short-chain fatty acids. Plays role in flagella synthesis, sodium (but not potassium) sensitivity and chemotaxis. |
3 | ftsZ | Cell division protein FtsZ | Q8RDQ7 | Required for proper localization of division plane during bacterial cytokinesis. Inhibition of its GTP-dependent polymerization activity prevents cells to divide |
4 | FN0724 | Flavodoxin | Q8RFH4 | Acts as an electron acceptor of pyruvate-oxidoreductase complex. Flavodoxin inhibitors were reported to act against Helicobacter pylori’s infection that causes gastritis or chronic peptic ulcers |
5 | FN0756 | Pseudouridine synthase | Q8RFE9 | Catalyze post-transcriptional modifications of cellular RNAs i.e., site-specific isomerisation of uridine. |
6 | rsgA | Putative ribosome biogenesis GTPase RsgA | Q8R685 | Involved in 30S ribosome subunit biogenesis. |
7 | FN0809 | Putative tRNA (cytidine(34)-2’-O)-methyltransferase | Q8R673 | Methylates 2’-O-ribose group of cytidine present at 34thposition of tRNA anticodon loop. |
8 | sigA | RNA polymerase sigma factor SigA | Q8RE13 | Essential for survival of bacteria as it regulates transcription of housekeeping promoters. |