Borrelia burgdorferi induces a type I interferon response during early stages of disseminated infection in mice

BMC Microbiology

Table 4 Transcripts significantly repressed in mouse blood in response to B. burgdorferi

Unigene	Gene symbol	Gene title	Gene ontology	FC^aB515	FC^aB331
Transcripts uniquely repressed by B. burgdorferi B515
Mm.1233	Fcer2a	Fc receptor, IgE, low affinity II, alpha polypeptide	Positive regulation of humoral Immune response mediated by circulating immunoglobulin	−3.34	−1.42
	Ighv14-2	immunoglobulin heavy variable 14-2		−2.59	−1.65
Mm.431426	Bach2	BTB and CNC homology 2	Regulation of transcription, DNA-dependent	−2.42	−1.80
Mm.476307	Zfp799	zinc finger protein	Regulation of transcription, DNA-dependent	−2.40	−1.39
Mm.126193	Tnik	TRAF2 and NCK interacting kinase	Protein phosphorylation	−2.39	−1.40
Mm.439662	Ebf1	early B cell factor	Transcription, DNA-dependent	−2.30	−1.28
Mm.486382	Gm8369	predicted gene 8369		−2.34	−1.90
Mm.482376	4833423F13	RIKEN cDNA 4833423F13 gene		−2.33	−1.31
Mm.482376	Rik	RIKEN cDNA 4833423F13 gene		−2.33	−1.31
Mm.441077	BC002059	cDNA sequence BC002059		−2.33	−1.65
Mm.1850	Fcrla	Fc receptor-like A	Cell differentiation	−2.21	−1.15
Mm.3411	Orc2	origin recognition complex, subunit 2	DNA replication	−2.06	−1.73
Transcripts repressed by B. burgdorferi B515 and B331
Mm.271744	Pfn2	profilin 2	Cytoskeleton organization	−3.14	−2.94
Mm.240047	Tnfrsf13c	tumor necrosis factor receptor	B-cell homeostasis	−2.10	−2.16
		superfamily, member 13c
Transcripts uniquely repressed by B. burgdorferi B331
Mm.41979	Mcpt8	mast cell protease 8	Proteolysis	−1.52	−2.60
Mm.273270	Cbll1	Casitas B-lineage lymphoma-like 1	Negative regulation of cell adhesion	−1.49	−2.30

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