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Table 3 Synonymous and nonsynonymous nucleotide substitutions within the emm type region (150 nt), based on Clustal W alignments corresponding to each emm type

From: Relationships between emm and multilocus sequence types within a global collection of Streptococcus pyogenes

emm pattern

No. of emm types (%)

No. of isolates analyzed

Average no. of nonsynonymous substitutions per nonsynonymous site (Ka) #

Average no. of synonymous substitutions per synonymous site (Ks)

Average ratio of Ka to Ks

A-C

18 (17)

137

0.02121

0.00431

4.92

D

40 (38)

155

0.00748

0.00488

1.53

E

44 (42) *

220

0.00732

0.00581

1.26

other^

3

8

0.02633

0.00721

3.65

All

105 (100)

520 $

0.01037

0.00526

1.96

  1. # Represents average of values from alignments corresponding to each emm type
  2. $ Sequence alignment of (partial) emm genes was performed for 520 of the 531 isolates.
  3. * emmst206 is included with emm96 analysis since the large indel (54 nt) is at the extreme 5' end.
  4. ^Includes two emm types associated with multiple emm patterns (emm54, emmst854; patterns A-C and D) and emm31 (pattern uncertain).
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BMC Microbiology

ISSN: 1471-2180

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