Figure 1

Typical time course plots resulting from simulation with our mathematical models; the red curves represent the number of EBs and the blue curves represent the number of RBs. We run the deterministic model to produce (a) normal development (with the doubling time t_d = 1.8 hrs, rate of RB detachment k = 1.3 hrs^-1, EB radius r_e = 0.1 μ m, rate of RB-to-EB differentiation μ = 0.25 hrs^-1, average spacing between T3S needles on the RB surface L = 0.04 μ m, length of T3S needles l _p = 0.0078 μ m, volume of host cell Cell_Vol = 2400 μ m³, proportion of cell not available for inclusion growth ε = 0.3, threshold number of T3S needles per RB P_lim = 23, number of inclusions N = 1, and RB radius r = 0.5 μ m) and (b) persistent infection (by increasing only the size of the RB radius, r = 2.0 μ m). Figures (c) and (d) show simulations of the stochastic model, using the same parameter values as used in (a) and (b) respectively.