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Figure 4 | BMC Microbiology

Figure 4

From: Altered cellular infiltration and cytokine levels during early Mycobacterium tuberculosis sigC mutant infection are associated with late-stage disease attenuation and milder immunopathology in mice

Figure 4

SCID mouse survival score and lung CFU counts. The mean CFU counts were obtained from the lung homogenates of at least 5 mice per group and plated on 7H10 agar plates (A). SCID mice received ~100 CFU per mouse via the aerosol route and these mice were sacrificed for either CFU counts or immunological assays 1, 14, 21 and 28 after infection. Day one CFU counts were performed to confirm the dose of bacilli in each group. Statistically significant differences between mice infected with the ΔsigC mutant strain and the CDC1551 strain were seen at days 14, 21 and 28 (* = p < 0.05). (B) From the Kaplan-Meier survival curve, the median survival for the ΔsigC mutant infected group is 86 days but 26 days for both the ΔsigC complemented mutant and the wild type strain, CDC1551. This difference is significant with a log rank test p value of < 0.002.

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BMC Microbiology

ISSN: 1471-2180

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