Table 1 Analysis of the giardial PI3K domains. Percentage identity values for the full-length and domain-only sequences of GiPI3K1 and GiPI3K2 with other PI3K isoforms following their sequence alignment.
GiPI3K1 | GiPI3K2 | |
|---|---|---|
Full- length | 39% to Dictyostelium discoideum PIK1, a Class I PI3K | 34% to Glycine max Vps34-like (Class III) PI3K |
Ras Binding Domain (RBD) | 41% to Homo sapiens Class IB p110γ PI3K | Absent |
PIK | 28% to H. sapiens Class IA p110α PI3K | 27% to Caenorhabditis elegans Vps34-like (Class III) PI3K |
Kinase | 39% to D. discoideum PIK1 | 33% to Glycine max Vps34-like (Class III) PI3K |