Activation of coagulation and tissue fibrin deposition in experimental influenza in ferrets

BMC Microbiology

Table 3 Correlation between virological parameters and markers of hemostasis

Correlation	H3N2	pH1N1	H5N1	H1N1 + H5N1	Influenza A
PT -Titer total^#	NS	-0.6 (-0.9—0.1) *	NS	-0.5 (-0.75- -0.1)*	NS
PT -AUC total^#	0.8 (0.4-0.9)***	0.7 (0.3-0.9)**	NS	0.4 (0.1-0.7)*	0.4 (0.2-0.7)**
PT -Body weight	NS	0.8 (0.4-0.9)**	NS	0.5 (0.1-0.7)*	0.5 (0.2-0.7)**
PT -Lung weight	NS	0.6 (0.05-0.9)*	NS	NS	0.4 (0.05-0.6)*
APTT -Titer total^#	-0.5 (-0.8 - -0.1)*	NS	NS	NS	NS
APTT -AUC total^#	0.8 (0.6-0.9)***	NS	NS	NS	0.3 (0.05-0.6)*
APTT -Body weight	NS	0.6 (0.2-0.9)**	NS	0.5 (0.1-0.7)**	0.4 (0.2-0.6)**
APTT -Lung weight	NS	NS	NS	NS	0.3 (0.1-0.6)*
VWF-Titer total^#	-0.6 (-0.8-0.1)*	NS	NS	NS	NS
VWF-AUC total^#	0.7 (0.4-0.9)**	NS	NS	NS	NS
VWF-Body weight	NS	NS	NS	NS	0.4 (0.1-0.6)*
VWF-Lung weight	NS	NS	NS	NS	NS
D-dimer -Titer total^#	NS	NS	NS	NS	NS
D-dimer -AUC total^#	NS	0.6 (0.2-0.8)*	NS	0.5 (0.1-0.7)*	0.4 (0.2-0.6 )**
D-dimer -Body weight	NS	0.7 (0.2-0.9)**	NS	0.5 (0.2-0.7)**	0.5 (0.2-0.7)***
D-dimer -Lung weight	NS	NS	NS	NS	NS
TAT -Titer total^#	NS	NS	NS	NS	0.3 (0.1-0.6)*
TAT -AUC total^#	NS	NS	NS	NS	NS
TAT -Body weight	NS	NS	0.6 (0.2-0.9)*	NS	NS
TAT -Lung weight	NS	NS	NS	0.5 (0.1-0.7)**	0.3 (0.01-0.5)*

Virological parameters are listed in Table 1. For each influenza virus group coagulation values were correlated to virological and clinical parameters. This was also done for the complete influenza A group (H3N2 + pH1N1 + H5N1) and for the combination of pH1N1 and H5N1 because these two viruses are able to infect the complete respiratory tract instead of only the upper respiratory tract which is the case for H3N2.
Pearson correlation coefficients are given if the values were statistically significant. *p <0.05 **p < 0.01 ***P < 0.001 if not significant NS is listed in the table.
Using Bonferroni correction for multiple comparison significance threshold is lowered to p < 0.01. Therefore results marked with ** and *** are considered statistically significant correlations.

ISSN: 1471-2180