Genotype designationsa
| PBP3 substitutionsb
|
---|
SSN | KTG |
---|
Categoryc
| Level | Group | S385 | R517 | N526 |
---|
rPBP3 | High | IIId
| T | | K |
| | III-likee
| T | H | |
| Low | II | | | K |
| | I | | H | |
sPBP3 | NA | NA | | | |
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aAccording to Ubukata et al.[7], Hasegawa et al.[8], Garcia-Cobos et al.[9], Hotomi et al.[10] and this study. NA, not applicable.
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bEssential amino acid substitutions in PBP3 (transpeptidase domain, 338–573) with the amino acid sequence of H. influenzae Rd KW20 [GenBank:U32793] as reference. SSN, Ser-Ser-Asn motif; KTG, Lys-Thr-Gly motif.
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crPBP3, isolates with PBP3 sequences conferring resistance to beta-lactams (isolates assigned to groups I, II, III-like and III); sPBP3, isolates with PBP3 sequences conferring wild-type susceptibility to beta-lactams (remaining isolates).
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dOriginally reserved for isolates with the additional substitutions M377I and L389F by Ubukata et al.[7], modification proposed by Hotomi et al.[10].
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eOriginally categorized as group I by Ubukata et al.[7], new group assignment proposed by Garcia-Cobos et al.[9].