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Table 2 Extra protein motifs in mycobacterial rhomboids

From: Rhomboid homologs in mycobacteria: insights from phylogeny and genomic analysis

Species/strain

Rhomboid

Number of aTMHs

TMH with active Site

Extra motif

E-value

Target signal

bH37Rv

Rv0110

7

4 & 6

DUF17511

0.27

Mitochondrial

    

Siva2

0.68

 
    

Zf-B_box3

0.00021

 

M. marinum

MMAR_0300

7

4 & 6

Zf-B_box

0.00012

Other

    

FixQ4

0.016

 

M. ulcerans

MUL_4822

7

4 & 6

EcsB5

0.17

Mitochondrial

cM. sp Jls

Mjls_5528

7

4 & 6

IBR6

0.301

Other

    

Zf-B_box

0.013

 
    

Dynactin p627

0.24

 
    

Tim178

0.36

 

M. vanbaalenii

Mvan_5753

7

4 & 6

Zf-B_box

0.0044

Other

    

Dynactin p62

0.11

 
    

DUF1751

0.028

 

M. gilvum

Mflv_1071

7

4 & 6

Zf-B_box

0.015

Other

    

DUF1751

0.02

 

M. smegmatis

MSMEG_5036

7

4 & 6

-

 

Mitochondrial

M. abscessus

MAB_0026

7

4 & 6

Zf-B_box

0.0064

Other

H37Rv

Rv1337

6

4 & 6

CBM_19

0.17

Mitochondrial

M. marinum

MMAR_4059

6

4 & 6

C_GCAxxG_C_C10

0.0062

Secretory

M. avium

MAV_1554

6

4 & 6

C_GCAxxG_C_C

0.0099

Secretory

M. leprae

ML1171

6

4 & 6

C_GCAxxG_C_C

0.031

Other

M. abscessus

MAB_1481

6

4 & 6

-

 

Other

M. smegamatis

MSMEG_4904

5

3 & 5

C_GCAxxG_C_C

0.025

Secretory

M. sp Jls

Mjls_3833

5

3 & 5

DUF215411

0.6

Secretory

M. vanbaalenii

Mvan_4290

5

3 & 5

-

 

Secretory

M. gilvum

Mflv_2355

5

3 & 5

-

 

Secretory

  1. The rhomboid family domain was excluded
  2. -: Extra domain not detected
  3. Other: cellular localization target other than secretory and mitochondrial
  4. a: Transmembrane helices
  5. b: Mycobacterium tuberculosis
  6. c: Mycobacterium species Jls
  7. 1: Eukaryotic integral membrane protein
  8. 2: Cd27 binding protein
  9. 3: B-box zinc finger
  10. 4:Cbb3-type cytochrome oxidase component
  11. 5: Bacterial ABC transporter protein
  12. 6: In Between Ring 'IBR' fingers
  13. 7: Dynactin p62 family
  14. 8: Tim17/Tim22/Tim23 family
  15. 9: Fungal cellulose binding domain
  16. 10: Putative redox-active protein
  17. 11: Predicted membrane protein