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Microbe-host interactions and microbial pathogenicity

Section edited by David Nelson

This section aims to publish studies looking at all aspects of microbe-host interactions and pathogenicity including pathogenic mechanisms, virulence factors, host invasion, immune evasion, host defence, immunity, immunology and symbiotic interactions.

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  1. We identified a HIV-positive cohort in virologic failure (VF) who re-suppressed without drug switch. We characterized their drug resistance mutations (DRM) and adherence profiles to learn how to better manage ...

    Authors: Chika K. Onwuamah, Jonathan Okpokwu, Rosemary Audu, Godwin Imade, Seema T. Meloni, Azuka Okwuraiwe, Philippe Chebu, Adesola Z. Musa, Beth Chaplin, Ibrahim Dalhatu, Oche Agbaji, Jay Samuels, Oliver Ezechi, Mukhtar Ahmed, Georgina Odaibo, David O. Olaleye…

    Citation: BMC Microbiology 2020 20:17

    Content type: Research article

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  2. The polysaccharide capsule is a major virulence factor of S. pneumoniae in diseases such as meningitis. While some capsular serotypes are more often found in invasive disease, high case fatality rates are associa...

    Authors: Annelies Müller, Anke Salmen, Suzanne Aebi, Linda de Gouveia, Anne von Gottberg and Lucy J. Hathaway

    Citation: BMC Microbiology 2020 20:16

    Content type: Research article

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  3. Francisella noatunensis subsp. orientalis (Fno) is the etiological agent of francisellosis in cultured warm water fish, such as tilapia. Antibiotics are administered to treat the disease but a better understandin...

    Authors: Winarti Achmad Sarmin Djainal, Khalid Shahin, Matthijs Metselaar, Alexandra Adams and Andrew P. Desbois

    Citation: BMC Microbiology 2020 20:8

    Content type: Research article

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  4. Harpins are proteins secreted by the type III secretion system of Gram-negative bacteria during pathogen–plant interactions that can act as elicitors, stimulating defense and plant growth in many types of non-...

    Authors: Yue Liu, Xiaoyun Zhou, Wenbo Liu, Jiamin Huang, Qinghuan Liu, Jianzhang Sun, Xinfeng Cai and Weiguo Miao

    Citation: BMC Microbiology 2020 20:4

    Content type: Research article

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  5. Scrub typhus causes up to 35% mortality if left untreated. One billion people living in the endemic regions are at risk. In spite of its heavy disease burden in some of the most populated areas in the world, t...

    Authors: Chien-Chung Chao, Ruoting Yang, Zhiwen Zhang, Tatyana Belinskaya, Chye-Teik Chan, Stacy-Ann Miller, Rasha Hammamieh, Marti Jett and Wei-Mei Ching

    Citation: BMC Microbiology 2020 20:3

    Content type: Research article

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  6. Many phytophagous insects, whose diet is generally nitrogen-poor, rely on gut bacteria to compensate for nutritional deficits. Accordingly, we hypothesized that insects in desert environments may evolve associ...

    Authors: Fengqun Meng, Nitsan Bar-Shmuel, Reut Shavit, Adi Behar and Michal Segoli

    Citation: BMC Microbiology 2019 19:311

    Content type: Research article

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  7. Gut microbiota has been increasingly acknowledged to shape significantly human health, contributing to various autoimmune diseases, both intestinal and non-intestinal, including multiple sclerosis (MS). Gut mi...

    Authors: Madina Kozhieva, Natalia Naumova, Tatiana Alikina, Alexey Boyko, Valentin Vlassov and Marsel R. Kabilov

    Citation: BMC Microbiology 2019 19:309

    Content type: Research article

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  8. Since animals frequently encounter a variety of harmful fungi in nature, their ability to develop sophisticated anti-fungal strategies allows them to flourish across the globe. Extensive studies have highlight...

    Authors: Wanzhen Su, Jialin Liu, Peng Bai, Baocang Ma and Wei Liu

    Citation: BMC Microbiology 2019 19:302

    Content type: Research article

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  9. Acinetobacter baumannii is an important opportunistic pathogen responsible for various nosocomial infections. The BfmRS two-component system plays a role in pathogenesis and antimicrobial resistance of A. baumann...

    Authors: Se Yeon Kim, Mi Hyun Kim, Seung Il Kim, Joo Hee Son, Shukho Kim, Yoo Chul Lee, Minsang Shin, Man Hwan Oh and Je Chul Lee

    Citation: BMC Microbiology 2019 19:301

    Content type: Research article

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  10. The neonatal meningitis E. coli (NMEC) strain S88 carries a ColV plasmid named pS88 which is involved in meningeal virulence. Transcriptional analysis of pS88 in human serum revealed a strong upregulation of an O...

    Authors: Mathieu Genuini, Philippe Bidet, Jean-François Benoist, Dimitri Schlemmer, Chloé Lemaitre, André Birgy and Stéphane Bonacorsi

    Citation: BMC Microbiology 2019 19:298

    Content type: Research article

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  11. Siberian sturgeon (Acipenser baeri Brandt) and Beluga sturgeon (Huso huso) are two important commercial fish in China, and the feeding habits of them are very different. Diets and feeding habits are two significa...

    Authors: Guanling Xu, Wei Xing, Tieliang Li, Min Xue, Zhihong Ma, Na Jiang and Lin Luo

    Citation: BMC Microbiology 2019 19:297

    Content type: Research article

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  12. MCC/eisosomes are membrane microdomains that have been proposed to participate in the plasma membrane function in particular by regulating the homeostasis of lipids, promoting the recruitment of specific prote...

    Authors: Justine Colou, Guillaume Quang N’Guyen, Ophélie Dubreu, Kévin Fontaine, Anthony Kwasiborski, Franck Bastide, Florence Manero, Bruno Hamon, Sophie Aligon, Philippe Simoneau and Thomas Guillemette

    Citation: BMC Microbiology 2019 19:295

    Content type: Research article

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  13. Childhood malnutrition is a global health challenge associated with multiple adverse consequences, including delayed maturation of the gut microbiota (GM) which might induce long-term immune dysfunction and st...

    Authors: Bingfeng Leng, Maria B. Sørensen, Witold Kot, Thomas Thymann, Lukasz Krych and Dennis S. Nielsen

    Citation: BMC Microbiology 2019 19:277

    Content type: Research article

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  14. Moraxella catarrhalis is a leading cause of otitis media (OM) and chronic obstructive pulmonary disease (COPD). M. catarrhalis contains a Type III DNA adenine methyltransferase (ModM) that is phase-variably expre...

    Authors: Luke V. Blakeway, Aimee Tan, Joseph A. Jurcisek, Lauren O. Bakaletz, John M. Atack, Ian R. Peak and Kate L. Seib

    Citation: BMC Microbiology 2019 19:276

    Content type: Research article

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  15. Gut microbes can contribute to their hosts in food digestion, nutrient absorption, and inhibiting the growth of pathogens. However, only limited studies have focused on the gut microbiota of freshwater snails. Po...

    Authors: Lan-Hua Li, Shan Lv, Yan Lu, Ding-Qi Bi, Yun-Hai Guo, Jia-Tong Wu, Zhi-Yuan Yue, Guang-Yao Mao, Zhong-Xin Guo, Yi Zhang and Yun-Feng Tang

    Citation: BMC Microbiology 2019 19:273

    Content type: Research article

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  16. Cardinium is an intracellular bacterial symbiont in the phylum Bacteroidetes that is found in many different species of arthropods and some nematodes. This symbiont is known to be able to induce three reproductiv...

    Authors: Corinne M. Stouthamer, Suzanne E. Kelly, Evelyne Mann, Stephan Schmitz-Esser and Martha S. Hunter

    Citation: BMC Microbiology 2019 19:266

    Content type: Research article

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  17. Oomycetes are pathogens of mammals, fish, insects and plants, and the potato late blight agent Phytophthora infestans and the oil palm and cocoa infecting pathogen Phytophthora palmivora cause economically impact...

    Authors: Edouard Evangelisti, Temur Yunusov, Liron Shenhav and Sebastian Schornack

    Citation: BMC Microbiology 2019 19:265

    Content type: Research article

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  18. Investigating the factors that influence Acinetobacter baumannii(Ab) adhesion/invasion of host cells is important to understand its pathogenicity. Metal cations have been shown to play an important role in regula...

    Authors: Yi Chen, Tingjun Shao, Sanhua Fang, Ping Pan, Jiahui Jiang, Tongtong Cheng, Haitong Wan and Daojun Yu

    Citation: BMC Microbiology 2019 19:264

    Content type: Research article

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  19. Quantification of intracellular bacteria is fundamental in many areas of cellular and clinical microbiology to study acute and chronic infections. Therefore, rapid, accurate and low-cost methods represent valu...

    Authors: Meysam Sarshar, Daniela Scribano, Giulia Tranquilli, Marisa Di Pietro, Simone Filardo, Carlo Zagaglia, Rosa Sessa, Anna Teresa Palamara and Cecilia Ambrosi

    Citation: BMC Microbiology 2019 19:252

    Content type: Methodology article

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  20. This study aimed to evaluate the safety of raw vegetable products present on the German market regarding toxin-producing Bacillus cereus sensu lato (s.l.) group bacteria.

    Authors: Gregor Fiedler, Carmen Schneider, Etinosa O. Igbinosa, Jan Kabisch, Erik Brinks, Biserka Becker, Dominic A. Stoll, Gyu-Sung Cho, Melanie Huch and Charles M. A. P. Franz

    Citation: BMC Microbiology 2019 19:250

    Content type: Research article

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  21. To explore the inhibition mechanism of Saccharomyces boulardii (S. boulardii) on ulcerative colitis (UC) carcinogenesis.

    Authors: Chunsaier Wang, Wenbin Li, Hongying Wang, Yiming Ma, Xinhua Zhao, Xudong Zhang, Hong Yang, Jiaming Qian and Jingnan Li

    Citation: BMC Microbiology 2019 19:246

    Content type: Research article

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  22. Cryptococcus neoformans, a basidiomycetous yeast, is a fungal pathogen that can colonize the lungs of humans causing pneumonia and fungal meningitis in severely immunocompromised individuals. Recent studies have ...

    Authors: Nadir Hani Dbouk, Madison Bailey Covington, Kenny Nguyen and Srikripa Chandrasekaran

    Citation: BMC Microbiology 2019 19:243

    Content type: Research article

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  23. The gut microbiota composition is known to be influenced by a myriad of factors including the host genetic profile and a number of environmental influences. Here, we focus on the environmental influence of coh...

    Authors: Casey T. Finnicum, Jeffrey J. Beck, Conor V. Dolan, Christel Davis, Gonneke Willemsen, Erik A. Ehli, Dorret I. Boomsma, Gareth E. Davies and Eco J. C. de Geus

    Citation: BMC Microbiology 2019 19:230

    Content type: Research article

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  24. Infective endocarditis (IE) is associated with high rates of mortality. Prolonged treatments with high-dose intravenous antibiotics often fail to eradicate the infection, frequently leading to high-risk surgic...

    Authors: Enea Gino Di Domenico, Sara Giordana Rimoldi, Ilaria Cavallo, Giovanna D’Agosto, Elisabetta Trento, Giovanni Cagnoni, Alessandro Palazzin, Cristina Pagani, Francesca Romeri, Elena De Vecchi, Monica Schiavini, Daniela Secchi, Carlo Antona, Giuliano Rizzardini, Rita Barbara Dichirico, Luigi Toma…

    Citation: BMC Microbiology 2019 19:228

    Content type: Research article

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  25. Caulerpa lentillifera is one of the most important economic green macroalgae in the world. Increasing demand for consumption has led to the commercial cultivation of C. lentillifera in Japan and Vietnam in recent...

    Authors: Zhourui Liang, Fuli Liu, Wenjun Wang, Pengyan Zhang, Xiutao Sun, Feijiu Wang and Heather Kell

    Citation: BMC Microbiology 2019 19:225

    Content type: Research article

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  26. Characterization of the skin and wound microbiome is of high biomedical interest, but is hampered by the low biomass of typical samples. While sample preparation from other microbiomes (e.g., gut) has been the...

    Authors: Samuel Verbanic, Colin Y. Kim, John M. Deacon and Irene A. Chen

    Citation: BMC Microbiology 2019 19:214

    Content type: Methodology article

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  27. Ustilago esculenta, a typical dimorphic fungus could infect Zizania latifolia and induce host stem swollen to form an edible vegetable called Jiaobai in China. The strains differentiation especially in the mating...

    Authors: Yafen Zhang, Min Wu, Qianwen Ge, Mengfei Yang, Wenqiang Xia, Haifeng Cui, Xiaoping Yu, Shangfa Zhang and Zihong Ye

    Citation: BMC Microbiology 2019 19:208

    Content type: Research article

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  28. Little is known about how bacterial endosymbionts colonize host tissues. Because many insect endosymbionts are maternally transmitted, egg colonization is critical for endosymbiont success. Wolbachia bacteria, ca...

    Authors: Steen Christensen, Moises Camacho, Zinat Sharmin, A. J. M. Zehadee Momtaz, Laura Perez, Giselle Navarro, Jairo Triana, Hani Samarah, Michael Turelli and Laura R. Serbus

    Citation: BMC Microbiology 2019 19:206

    Content type: Methodology article

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  29. Lactobacilli are gatekeepers of vaginal ecosystem impeding growth of pathogenic microbes and their diversity varies across populations worldwide. The present study investigated diversity of human vaginal micro...

    Authors: Sumi Das Purkayastha, Mrinal Kanti Bhattacharya, Himanshu Kishore Prasad, Hrishikesh Upadhyaya, Suparna Das Lala, Kunal Pal, Meenakshi Das, Gauri Dutt Sharma and Maloyjo Joyraj Bhattacharjee

    Citation: BMC Microbiology 2019 19:198

    Content type: Research article

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  30. More than half of the adult population worldwide is overweight or obese, while excess adiposity has been linked to chronic low-grade inflammation, contributing to the development of chronic diseases. Recent st...

    Authors: Su Jeong Kim, Sung-Eun Kim, A-Reum Kim, Saemyi Kang, Mi-Young Park and Mi-Kyung Sung

    Citation: BMC Microbiology 2019 19:193

    Content type: Research article

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  31. Gut microbiota has been suggested to play a role in stroke patients. Nevertheless, little is known about gut microbiota and the clinical indexes in stroke patients.

    Authors: Na Li, Xingcui Wang, Congcong Sun, Xinwei Wu, Mei Lu, Youfeng Si, Xiang Ye, Tan Wang, Xiaolin Yu, Xinjing Zhao, Na Wei and Xingbang Wang

    Citation: BMC Microbiology 2019 19:191

    Content type: Research article

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  32. The low bacterial load in samples acquired from the lungs, have made studies on the airway microbiome vulnerable to contamination from bacterial DNA introduced during sampling and laboratory processing. We hav...

    Authors: Christine Drengenes, Harald G. Wiker, Tharmini Kalananthan, Eli Nordeide, Tomas M. L. Eagan and Rune Nielsen

    Citation: BMC Microbiology 2019 19:187

    Content type: Research article

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  33. Vibrio parahaemolyticus (V. parahaemolyticus) is a leading cause of food poisoning and is of great importance to public health due to the frequency and seriousness of the diseases. The simple, timely and efficien...

    Authors: Yunyun Geng, Ke Tan, Libing Liu, Xiao Xia Sun, Baohua Zhao and Jianchang Wang

    Citation: BMC Microbiology 2019 19:186

    Content type: Methodology article

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  34. The Chinese believe that the meat of pigs reared in the past with free range tastes better than that of the pigs reared indoor on a large scale today. Gastrointestinal microflora is closely associated with the...

    Authors: Keke Qi, Xiaoming Men, Jie Wu and Ziwei Xu

    Citation: BMC Microbiology 2019 19:181

    Content type: Research article

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  35. The human gastrointestinal (GI) tract microbiota has been a subject of intense research throughout the 3rd Millennium. Now that a general picture about microbiota composition in health and disease is emerging,...

    Authors: Oula Peñate-Medina, Robert J. Tower, Tuula Peñate-Medina, Olga Will, Per E. J. Saris, Juho Suojanen, Timo Sorsa, Laura Huuskonen, Kaisa Hiippala, Reetta Satokari, Claus C. Glüer, Willem M. de Vos and Justus Reunanen

    Citation: BMC Microbiology 2019 19:167

    Content type: Research article

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  36. Enteric pathogens have developed mechanisms to disrupt tight junctions and increase gut permeability. Many studies have analysed the ability of live probiotics to protect intestinal epithelial cells against ti...

    Authors: Carina-Shianya Alvarez, Rosa Giménez, María-Alexandra Cañas, Rodrigo Vera, Natalia Díaz-Garrido, Josefa Badia and Laura Baldomà

    Citation: BMC Microbiology 2019 19:166

    Content type: Research article

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  37. We previously identified a plant-derived phenolic compound ortho-coumaric acid (OCA) as an inhibitor of type III secretion system (T3SS) of Xanthomonas oryzae pv. oryzae (Xoo), the pathogen causing bacterial leaf...

    Authors: Susu Fan, Fang Tian, Liwei Fang, Ching-Hong Yang and Chenyang He

    Citation: BMC Microbiology 2019 19:163

    Content type: Research article

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  38. H. pylori exhibits antibiotic resistance with regional differences. In this paper, we explored antibiotic resistance of H. pylori to five antibiotics in an area with a high risk of gastric cancer.

    Authors: Dan Wang, Qianqian Guo, Yuan Yuan and Yuehua Gong

    Citation: BMC Microbiology 2019 19:152

    Content type: Research article

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  39. Adaptability to different environmental conditions is an essential characteristic of pathogenic microorganisms as it facilitates their invasion of host organisms. The most external component of pathogenic yeas...

    Authors: Justyna Karkowska-Kuleta, Dorota Satala, Oliwia Bochenska, Maria Rapala-Kozik and Andrzej Kozik

    Citation: BMC Microbiology 2019 19:149

    Content type: Research article

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  40. The brown planthopper (BPH) is likely the most destructive, piercing and sucking monophagous insect pest of rice that causes substantial economic losses to farmers. Although yeast-like symbionts (YLS) and virus t...

    Authors: Abhishek Ojha and Wenqing Zhang

    Citation: BMC Microbiology 2019 19:139

    Content type: Research article

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  41. Pseudomonas aeruginosa is an opportunistic pathogen and one of the leading causes of nosocomial infections. Moreover, the species can cause severe infections in cystic fibrosis patients, in burnt victims and caus...

    Authors: Anna Cristhina Carmine de Melo, Amanda da Mata Gomes, Fernando L. Melo, Daniel M. P. Ardisson-Araújo, Agueda Palmira Castagna de Vargas, Valessa Lunkes Ely, Elliot W. Kitajima, Bergmann M. Ribeiro and José Luiz Caldas Wolff

    Citation: BMC Microbiology 2019 19:134

    Content type: Research article

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  42. Xenorhabdus spp. live in close symbiosis with nematodes of the Steinernema genus. Steinernema nematodes infect an insect larva and release their symbionts into the haemocoel of the insect. Once released into the ...

    Authors: J. Dreyer, M. Rautenbach, E. Booysen, A. D. van Staden, S. M. Deane and L. M. T. Dicks

    Citation: BMC Microbiology 2019 19:132

    Content type: Research article

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  43. Treatment with the α-glucosidase inhibitor acarbose increases median lifespan by approximately 20% in male mice and 5% in females. This longevity extension differs from dietary restriction based on a number of fe...

    Authors: Byron J Smith, Richard A Miller, Aaron C Ericsson, David C Harrison, Randy Strong and Thomas M Schmidt

    Citation: BMC Microbiology 2019 19:130

    Content type: Research article

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  44. Enteric methane from the ruminant livestock is a significant source in global greenhouse gas emissions, which is mainly generated by the methanogens inhabiting the rumen and cecum. Sika deer (Cervus nippon) not o...

    Authors: Zhipeng Li, Xiaoxu Wang, Ting Zhang, Huazhe Si, Chao Xu, André-Denis G. Wright and Guangyu Li

    Citation: BMC Microbiology 2019 19:129

    Content type: Research article

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  45. Gut microbes have been suggested as the possible targets in the management of allergic diseases. However, the way in which these microbes influence allergic diseases remain unclear. Forty-seven full-term newbo...

    Authors: Xi Shen, Maolin Wang, Xiao Zhang, Miao He, Ming Li, Guo Cheng, Chaomin Wan and Fang He

    Citation: BMC Microbiology 2019 19:123

    Content type: Research article

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  46. Bluetongue virus (BTV) causes a disease among wild and domesticated ruminants which is not contagious, but which is transmitted by biting midges of the Culicoides species. BTV can induce an intense cytopathic eff...

    Authors: Junzheng Du, Shandian Gao, Zhancheng Tian, Yanni Guo, Di Kang, Shanshan Xing, Guorui Zhang, Guangyuan Liu, Jianxun Luo, Huiyun Chang and Hong Yin

    Citation: BMC Microbiology 2019 19:121

    Content type: Research article

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  47. Trichosporon is the dominant genus of epidermal fungi in giant pandas (Ailuropoda melanoleuca) and causes local and deep infections. To provide the information needed for the diagnosis and treatment of trichospor...

    Authors: Xiaoping Ma, Yaozhang Jiang, Chengdong Wang, Yu Gu, Sanjie Cao, Xiaobo Huang, Yiping Wen, Qin Zhao, Rui Wu, Xintian Wen, Qigui Yan, Xinfeng Han, Zhicai Zuo, Junliang Deng, Zhihua Ren, Shumin Yu…

    Citation: BMC Microbiology 2019 19:113

    Content type: Research article

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  48. Knowledge of microbiota composition, persistence, and transmission as well as the overall function of the bacterial community is important and may be linked to honey bee health. This study aimed to investigate...

    Authors: Zuzana Hroncova, Jiri Killer, Josef Hakl, Dalibor Titera and Jaroslav Havlik

    Citation: BMC Microbiology 2019 19:110

    Content type: Research article

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