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Fig. 1 | BMC Microbiology

Fig. 1

From: Caenorhabditis elegans DAF-16 regulates lifespan and immune responses to Cryptococcus neoformans and Cryptococcus gattii infections

Fig. 1

Defects in insulin/IGF-1 signaling pathway (IIS) components regulate the lifespan of C. elegans after feeding with C. neoformans and C. gattii. A a schematic diagram of the C. elegans-cryptococcal killing model. Wild-type and transgenic C. elegans at D1 adult were feeding on the lawns of C. neoformans 32045, C. gattii 56992, and E. coli OP50 on BHI plates at 25 °C. Percentages of survival of cryptococcal infected- B wild-type, C sek-1(ag1), D age-1(hx546), E daf-16(mu86), F jnk-1(gk7), G sir-2.1(ok434), and H osr-1(rm1) strains (n = 50). Worms being fed with E. coli OP50 were served as mock-infected controls. Lifespan was analyzed by Kaplan–Meier analysis and P‐values were obtained from the log‐rank test. Statistical details of lifespan in each C. elegans strain are summarized in Table 1

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