Fig. 1From: Caenorhabditis elegans DAF-16 regulates lifespan and immune responses to Cryptococcus neoformans and Cryptococcus gattii infectionsDefects in insulin/IGF-1 signaling pathway (IIS) components regulate the lifespan of C. elegans after feeding with C. neoformans and C. gattii. A a schematic diagram of the C. elegans-cryptococcal killing model. Wild-type and transgenic C. elegans at D1 adult were feeding on the lawns of C. neoformans 32045, C. gattii 56992, and E. coli OP50 on BHI plates at 25 °C. Percentages of survival of cryptococcal infected- B wild-type, C sek-1(ag1), D age-1(hx546), E daf-16(mu86), F jnk-1(gk7), G sir-2.1(ok434), and H osr-1(rm1) strains (n = 50). Worms being fed with E. coli OP50 were served as mock-infected controls. Lifespan was analyzed by Kaplan–Meier analysis and P‐values were obtained from the log‐rank test. Statistical details of lifespan in each C. elegans strain are summarized in Table 1Back to article page