Table 1 MIC and FICI results with the combinations of MIN and azoles against Scedosporium apiospermum
Strain | MIC (ug/mL) for: | ||||||
|---|---|---|---|---|---|---|---|
Agent alone | Combination [A/B(ug/mL)] (FICI) | ||||||
MIN | ITR | VOR | POS | MIN/ITR | MIN/VOR | MIN/POS | |
Scedosporium aurantiacum (CBS 116910) | ≥16 | 8 | 0.5 | 2 | 4/2(S) | 4/0.25(I) | 8/0.5(S) |
Scedosporium minutispora (CBS 116911) | ≥16 | 2 | 0.25 | 2 | 4/0.25(S) | 8/0.25(I) | 8/0.5(S) |
Scedosporium boydii (CBS 101.22) | ≥16 | 2 | 0.25 | 2 | 8/1(I) | 16/0.25(I) | 4/0.5(S) |
Lomentospora prolificans (CBS 467.74) | ≥16 | ≥16 | 16 | ≥16 | 4/8(S) | 4/8(I) | 4/8(S) |
Scedosporium dehoogii (CBS 117406) | ≥16 | 2 | 0.5 | 2 | 4/1(I) | 4/0.5(I) | 8/0.5(S) |
Scedosporium apiospermum (CBS 116899) | ≥16 | 4 | 0.25 | 2 | 4/1(S) | 4/0.25(I) | 8/0.5(S) |
Scedosporium boydii (1) | >16 | >16 | 1 | 2 | 8/1 (S) | 8/0.25(I) | 8/0.5(S) |
Scedosporium boydii (2) | >16 | 4 | 1 | 1 | 4/1(S) | 8/0.25(I) | 8/0.25(S) |
Scedosporium boydii (3) | >16 | >16 | 1 | 4 | 8/2(S) | 8/0.5(I) | 8/1(S) |
Scedosporium apiospermum (4) | >16 | >16 | 1 | 4 | 8/4(S) | 8/0.25(I) | 4/1(S) |
Scedosporium apiospermum (5) | >16 | >16 | 1 | 2 | 8/4(S) | 8/0.5(I) | 8/0.5(S) |
Scedosporium apiospermum (6) | >16 | >16 | 0.5 | 2 | 8/4 (S) | 4/0.5 (I) | 8/0.5(S) |
Lomentospora prolificans (7) | >16 | >16 | >16 | >16 | 16/16(I) | 16/16(I) | 16/16(I) |
Scedosporium minutisporum (8) | >16 | 8 | 1 | 2 | 8/2(S) | 8/0.25(S) | 8/0.5(S) |
Scedosporium apiospermum (9) | >16 | >16 | 0.5 | 4 | 8/16(I) | 8/0.125(I) | 8/1(S) |
Scedosporium boydii (10) | >16 | 4 | 0.25 | 1 | 4/1(S) | 8/0.125 (I) | 8/0.25(S) |