Table 1 Strain identifier, strain type, Isolation source, capsular type, and sequence type (ST) of clinical strains of Streptococcus agalactiae used in this study and the minimum inhibitory concentration (MIC) of zinc chloride required to suppress growth (as determined by OD600) by comparison with growth in medium alone lacking zinc supplementation (P < 0.05, Student’s t test)
Strain Identifier | Strain Type | Sequence Type | Capsular Serotype | Isolation Source | Growth MIC |
|---|---|---|---|---|---|
GB0002 | Colonizing | ST-23 | cpsIa | Vaginal/rectal colonization | 2500 μM |
GB0012 | Colonizing | ST-1 | cpsV | Vaginal/rectal colonization | 500 μM |
GB0037 | Invasive | ST-1 | cpsV | EOD/sepsis | 1000 μM |
GB0064 | Invasive | ST-17 | cpsIII | EOD/sepsis | 2500 μM |
GB0066 | Invasive | ST-19 | cpsIII | EOD/sepsis | > 5000 μM |
GB0069 | Invasive | ST-17 | cpsIII | EOD/sepsis | 2500 μM |
GB0079 | Invasive | ST-19 | cpsIII | EOD/sepsis | > 5000 μM |
GB0083 | Colonizing | ST-1 | cpsVI | Vaginal/rectal colonization | 125 μM |
GB0112 | Colonizing | ST-12 | cpsIII | Vaginal/rectal colonization | 500 μM |
GB0115 | Colonizing | ST-17 | cpsIII | Vaginal/rectal colonization | 2500 μM |
GB0241 | Colonizing | ST-23 | cpsV | Vaginal/rectal colonization | 1000 μM |
GB0285 | Colonizing | ST-12 | cpsII | Vaginal/rectal colonization | 2500 μM |
GB0291 | Colonizing | ST-12 | cpsII | Vaginal/rectal colonization | 2500 μM |
GB0374 | Invasive | ST-12 | cpsIb | EOD/sepsis | 2500 μM |
GB0377 | Invasive | ST-19 | cpsIII | EOD/sepsis | > 5000 μM |
GB0390 | Invasive | ST-23 | cpsIa | EOD/sepsis | > 5000 μM |
GB0397 | Invasive | ST-23 | cpsIII | EOD/sepsis | 1000 μM |
GB0411 | Invasive | ST-17 | cpsIII | EOD/sepsis | 750 μM |
GB0418 | Invasive | ST-17 | cpsIII | EOD/sepsis | 2500 μM |
GB0438 | Invasive | ST-12 | cpsIb | LOD/sepsis | 1000 μM |
GB0561 | Colonizing | ST-19 | cpsV | Vaginal/rectal colonization | 125 μM |
GB0571 | Colonizing | ST-19 | cpsIII | Vaginal/rectal colonization | 250 μM |
GB0590 | Colonizing | ST-19 | cpsIII | Vaginal/rectal colonization | > 5000 μM |
GB0651 | Colonizing | ST-19 | cpsIb | Vaginal/rectal colonization | 125 μM |
GB0653 | Colonizing | ST-12 | cpsII | Vaginal/rectal colonization | 1000 μM |
GB0654 | Colonizing | ST-17 | cpsIII | Vaginal/rectal colonization | 2500 μM |
GB0663 | Colonizing | ST-19 | cpsIII | Vaginal/rectal colonization | > 5000 μM |
NEM316 | Invasive | ST-23 | cpsIII | EOD/sepsis | 500 μM |
COH1 | Invasive | ST-17 | cpsIII | Blood | 750 μM |
A909 | Invasive | ST-7 | cpsIa | Blood/sepsis | 125 μM |