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Fig. 3 | BMC Microbiology

Fig. 3

From: Investigating the effect of an identified mutation within a critical site of PAS domain of WalK protein in a vancomycin-intermediate resistant Staphylococcus aureus by computational approaches

Fig. 3

The location of Zn2 + −binding sites in WalK protein. (A) The Zn2+-binding residues (HIS 271, ASP 274, HIS 364, and GLU 368) of WalK protein coordinated with Zn2+. Blue rods show the Zn2+-binding residues. The coordinating bonds are shown with purple lines and numbers (1, 2, 3, 4, and 5). The image is generated by Protein-Ligand Interaction Profiler (PLIP) web service (https://projects.biotec.tu-dresden.de/plip-web/plip/index). PDB ID 4mn6 was used as a wild-type template. (B) Alignment of residues 271-370 of WalK protein in S. aureus with other staphylococci, bacilli, and enterococci. Zn2+-binding residues are shown in red colour. The mutated residue in VAN-I is highlighted in yellow. The nonconserved residues are highlighted in blue

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