Fig. 2
OTU41 is the only significantly different OTU between the cranberry and control cohorts. a Distribution of OTU relative abundance differences between cranberry and control cohorts. The X axis represents the difference of the log2 median fold-change of cranberry to placebo cohorts for each OTU. The Y axis is the -log10 unadjusted p-value of the Wilcoxon rank sum test for each OTU. The size of the point represents the magnitude of the median change in the OTU relative abundance in the cranberry cohort, while the color indicates the direction of said change (blue = decrease, gray = no change, red = increase). Only OTU41 (shown in the top left) was significant after correction (adjusted p = 0.02). b The relative abundance of OTU41 decreased significantly in the cranberry beverage cohort. c A phylogenetic tree, based on 16S V4 regions, of OTU41 together with the other OTUs from this study assigned to the Flavonifractor genus, as well as additional sequenced strains closely related to Flavonifractor, including Flavonifractor sp. 54, Flavonifractor plautii, Lachnospiraceae bacterium, Flintibacter butyricus, Pseudoflavonifractor sp., and Pseudoflavonifractor capillosus indicated a very close relationship between OTU41 and Flavonifractor sp. 54. Relevant bootstrap values are shown. d Alignment of the 16S V4 sequence for OTU41 and Flavonifractor sp. 54, showing only one base pair difference