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Table 2 Ciprofloxacin (CIP) and norfloxacin (NOR) susceptibility data for the 22 GC strains with details of GyrA, ParC, MtrR and PorB amino acid substitutions, and mtrR promoter mutation

From: gyrA and parC mutations in fluoroquinolone-resistant Neisseria gonorrhoeae isolates from Kenya

Isolate ID

MIC(mg/L)

Mutations

Gyr A

Par C

MtrR

A13deletion

PorB

 

CIP

NOR

S91

D95

E91

A39

G45

H105

A121

G120

N122

KNY_NGAMR1

0.38

1.5

F

G

        

KNY_NGAMR2

0.016a

0.094

    

D

 

A deleted

 

D

 

KNY_NGAMR3

3

6

F

G

G

T

      

KNY_NGAMR4

0.006a

0.023

   

T

   

S

 

K

KNY_NGAMR5

4

6

F

G

G

  

Y

    

KNY_NGAMR6

12

12

F

G

G

T

      

KNY_NGAMR7

8

12

F

G

G

    

S

 

K

KNY_NGAMR8

3

6

F

A

 

T

      

KNY_NGAMR9

12

0.24

F

A

G

T

      

KNY_NGAMR10

8

12

F

G

G

T

      

KNY_NGAMR11

3

8

F

A

 

T

      

KNY_NGAMR13

3

12

F

A

 

T

      

KNY_NGAMR14

16

24

F

G

G

T

   

S

 

K

KNY_NGAMR15

4

16

F

A

 

T

      

KNY_NGAMR16

8

6

F

G

G

T

      

KNY_NGAMR17

6

12

F

G

G

  

Y

    

KNY_NGAMR18

0.38

0.047

F

G

G

T

      

KNY_NGAMR19

4

8

F

G

G

T

      

KNY_NGAMR20

8

12

F

A

G

T

      

KNY_NGAMR21

3

8

F

A

 

T

      

KNY_NGAMR22

4

12

F

G

G

T

      

KNY_NGAMR23

12

12

F

A

G

T

      
  1. GyrA S91F and D95G/A amino acid substitutions were found in 20 ciprofloxacin resistant isolates. Of the 20 isolates, 14 had an additional ParC E91G substitution. Two ciprofloxacin susceptible isolates lacked the QRDR mutations associated with fluoroquinolone resistance
  2. a-ciprofloxacin susceptible