From: Gut microbiota of preterm infants supplemented with probiotics: sub-study of the ProPrems trial
 | Probiotic, n = 38 | Placebo, n = 28 | P valuea |
---|---|---|---|
Demographics | |||
Male, n (%) | 19 (50.0) | 14 (50.0) | 1.0 |
Gestational age, wk., mean (SD) | 28.6 (1.81) | 27.5 (1.72) | 0.02 |
Birth weight, g, mean (SD) | 1040 (285) | 1000 (253) | 0.53 |
Maternal antibiotics, n (%)b | 20 (52.6) | 12 (42.9) | 0.43 |
Infant antibiotics: | |||
 Courses of antibiotics, median (IQR)) | 1 (0–2) | 1 (0–2) | 0.48 |
 Days of antibiotic exposure, d, median (IQR) | 2 (0–8) | 5 (0–10) | 0.38 |
Infants with at least 1 episode of definite late-onset sepsis with pathogen, n(%)c | 3 (7.9) | 2 (7.1) | 1.0 |
Infants with at least 1 episode of definite late-onset sepsis with CoNS, n(%)c | 2 (5.3) | 4 (14.3) | 0.39 |
Caesarean delivery, n (%) | 27 (71.1) | 19 (60.7) | 0.78 |
Any breast milk feeding, n (%) | 37 (97.4) | 28 (100.0) | 1.0 |
Age commenced study powder, d, median (IQR) | 3.0 (2.0–5.0) | 3.5 (2.0–5.5) | 0.51 |
Age finished study powder, d, median (IQR) | 67.5 (54.0–85.0) | 73.0 (64.0–89.5) | 0.14 |
Length of supplementation, d, median (IQR) | 62.5 (48.5–81.8) | 69.5 (62.0–83.3) | 0.17 |
Sequencing data | |||
Specimens included, n | 124 | 91 | Â |
Specimens collected before supplementation commenced, n | 3 | 8 | Â |
DOL, median (range) | 3 (3–4) | 4 (1–8) |  |
Specimens collected during supplementation period, n | 80 | 62 | Â |
DOL, median (range) | 30 (6–72) | 31 (4–96) |  |
Specimens collected post supplementation period, n | 41 | 21 | Â |
DOL, median (range) | 256 (58–529) | 285 (61–613) |  |
Specimens collected per baby, mean (SD) | 3 (0.8) | 3 (0.8) | Â |
Number of reads per specimen, median (IQR) | 3296 (1729–5136) | 3076 (1654–4472) | 0.39 |