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Fig. 1 | BMC Microbiology

Fig. 1

From: The therapeutic potential of bacteriophages targeting gram-negative bacteria using Galleria mellonella infection model

Fig. 1

Impact of single dose phage treatment on E. coli ec311, K. pneumoniae kp235 and E. cloacae el140 infection and survival rates of G. mellonella larvae. A single phage dose (104 PFU/mL) was injected at 0th hour after the larvae was pre-infected with 108 CFU/mL of bacteria. a Saline, phage and bacteria only control group larval survival. b Survival rates of the larvae infected with E. coli ec311 treated with single dose of Escherichia phage ECP311 (p = 0.0045). c Survival rates of the larvae infected with K. pneumoniae kp235 treated with single dose Klebsiella phage KPP235 (p = 0.0006). d Survival rates of larvae infected with E. cloacae el140 treated with Enterobacter phage ELP140 (p = 0.0052). The survival rates were plotted using the Kaplan-Meier method and log-rank test was used to analyze the difference in survival rates in GraphPad Prism 7.0. All phage treatment results were compared with the control. A statistically significant difference (p < 0.05) was observed using 10 worms per group on phage treatment

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