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Fig. 8 | BMC Microbiology

Fig. 8

From: Beta-defensin derived cationic antimicrobial peptides with potent killing activity against gram negative and gram positive bacteria

Fig. 8

Effects of protease treatment on the antimicrobial activity of CAMP-A and CAMP-B against P. aeruginosa and S. aureus. Peptides were digested with α-chymotrypsin, elastase, matrilysin, or cathepsin B for 1 h at 37 °C and subjected to SDS-PAGE (16.5% polyacrylamide gel) analysis. a CAMP-(a). b CAMP-(b). c Antimicrobial activity of CAMP-A post-digestion by α-chymotrypsin at the concentration of 0.12, 0.66, and 1.2 μg/ml. d Antimicrobial activity of CAMP-B post-digestion by α-chymotrypsin at the concentration of 0.12, 0.66, and 1.2 μg/ml. Results are expressed as percent killing by digested peptides over untreated peptides. Data are expressed as the means ± SD of three independent experiments. An asterisk indicates a statistically significant difference between antimicrobial activity with and without protease (*p < 0.05 and **p < 0.01)

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BMC Microbiology

ISSN: 1471-2180

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