From: A Recurrent Silent Mutation Implicates fecA in Ethanol Tolerance by Escherichia coli
Function | Gene | Mutation | Description | Notes |
---|---|---|---|---|
Ethanol pathway | ldhA | insertion ca. T152 | D-lactate dehydrogenase | b,c |
pflB | 5′ del up to S397 | Pyruvate formate lyase | b | |
Cellular respiration | dcuS | T198I | Histidine protein kinase; regulates anaerobic fumarate metabolism in response to extracellular fumarate concentrations | Â |
Cell wall | mltA | S268G | Transglycosylation of the muramic acid residue | Â |
Membrane transport | focA | del | Membrane protein; formate export | b |
gcvB | insertion ~ nt 2,940,787 | sRNA that represses oppA, dppA, gltI and livJ | d | |
Metabolic functions | gatY | insertion ca. E149 | Encodes tagatose-bisphosphate aldolase | c |
Protein synthesis | ycaO | 3′ del starting at A565 | Ribosomal protein S12 methylthiotransferase accessory factor |  |
Transcription | rpoA | L300F | RNA polymerase alpha subunit | Â |
rpoS | Q33stop | RNA polymerase sigma subunit | e,f | |
Pseudogenes | intQ | F261Â L | Â | Â |
Unknown function | ylbE | E39E | Domain of unknown function 1116 family member; induced by NO | Â |
yphD | possible insertion ~ V236 | ABC transporter of unknown function | Â | |
Insertion sequences, transposons, and repetitive elements | RIP321 | CG insertion at nt 4,294,403 | Repetitive element | Â |
Mutations outside of known genes | Â | possible insertion ~ nt 2,985,196 | between yqeG (putative hydroxy/aromatic amino acid permease) and yqeH (predicted LuxR family transcriptional regulator) | Â |
 |  | C → T at nt 3,957,957 | between ppiC (peptidylprolyl-cis-trans isomerase; protein folding) and yifO (hypothetical conserved protein) |  |