Fig. 5

Altered protein abundance upon gentamicin (G) treatment in E. coli WT or cpxAR mutant cells. In the heatmap, relative proteins intensities are visualized, thereby red fields indicate higher relative intensities, dark blue lower relative intensities and grey fields show relative intensities around one. In addition, gentamicin treatment depending ratios between the WT and the cpxAR mutant are presented as well, ratios to the control >2 are labeled red, those <0.5 in blue. Proteins are grouped by CpxAR or ArcA dependence. Some proteins were already described to be Cpx targets [(1) Surmann et al. (2016) [34]], found regulated upon gentamicin on transcript level [(2), Kohanski et al. (2008) [8]], and/or positively (+) or negatively (−) CpxR ~ P or ArcA ~ P-regulated [(3) Batchelor et al. (2005) [69], (4) Wyborn et al. (2002) [70], (5) Zientz et al. (1999) [71], (6) Iuchi et al. (1990) [20], (7) Salmon et al. (2005) [72], (8) Liu & de Wulf (2004) [44], (9) Richard et al. (1999) [73], (10) Shalel-Levanon et al. (2005) [74], (11) Kaiser & Sawers (1997) [75]]