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Table 1 Genetic variations among the NDM-1 and its variants and its first source of spread

From: Structure, Genetics and Worldwide Spread of New Delhi Metallo-β-lactamase (NDM): a threat to public health

NDM-1 variants Amino acid(s) substitution Source organism(s)
NDM-2 Proline 28 to Alanine Acinetobacter baumannii
NDM-3 Aspartate 95 to Asparagine Escherichia coli
NDM-4 Methionine 154 to Leucine Escherichia coli
NDM-5 Valine 88 to Leucine
Methionine 154 to Leucine
Escherichia coli
NDM-6 Alanine 233 to Valine Escherichia coli
NDM-7 Aspartate 130 to Asparagine
Methionine 154 to Leucine
Escherichia coli
NDM-8 Aspartate 130 to Glycine
Methionine 154 to Leucine
Escherichia coli
NDM-9 Glutamic Acid 152 to Lysine Klebsiella pneumoniae
NDM-10 Arginine 32 to Serine,
Glycine 36 toAspartic acid,
Glycine 69 to serine,
Alanine 74 to threonine,
Glycine 200 to Arginine
Klebsiella pneumoniae
NDM-11 NA Escherichia coli
NDM-12 Glycine 222 to Aspartic acid and Methionine 154 to Leucine Escherichia coli
NDM-13 Aspartic acid 95 to Asparagine and Methionine 154 to Leucine Escherichia coli
NDM-14 Aspartic acid 130 to Glycine Acinetobacter lwoffii
NDM-15 Alanine 233 to valine
Methionine 154 to Leucine
Escherichia coli
NDM-16 Arginine 264 to Histidine Klebsiella pneumoniae
NDM-17 Valine 88 to Leucine, Methionine 154 to Leucine and Glutamic acid 170 to Lysine Escherichia coli