Table 1 The inhibition values of active compounds for Alr-2
From: Selection and characterization of alanine racemase inhibitors against Aeromonas hydrophila
Hits | Inhibitor | MW | Structure | aIC50 (μM) | bIC50 (μM) | cMIC (μg/ml) | dMIC (μg/ml) | eTC50 (μg/ml) | fTi | |
|---|---|---|---|---|---|---|---|---|---|---|
I-1 | Anabellamide | 583.626 |
| 6.6(0.19) | NC | NC | ||||
I-2 | Patulin | 154.12 |
| 14.7(0.27) | 20(0.89) | 80(3.96) | NC | NC | ||
I-3 | Homogentisic acid | 168.147 |
| 12.5(0.2) | 120(1.73) | NC | 157.7(6.1) | 1.3 | ||
I-4 | Acetic acid,[4-(5-butyl-5-methyl-2(5H)-furanylidene)dihydro −3,5-dioxo-2(3H)-furanylidene]-(9CI) | 292.284 |
| 8.9(0.34) | NC | NC | ||||
I-5 | Propyl Gallate | 212.2 |
| 8.6(0.5) | NC | NC | ||||
I-6 | Hydroquinone | 110.11 |
| 18.5(0.18) | 80(2.6) | 140(2.4) | 122.9(8.9) | 1.54 | ||
I-7 | Benzenepropanoic acid,2-(9-acridinylamino)- monohydrochloride | 378.85 |
| 17.7(0.34) | NC | NC | ||||
I-8 | Haematoxylin | 302.29 |
| 15.6(0.23) | NC | NC | ||||
I-9 | Higenamine | 271.32 |
| 14.3(0.21) | NC | NC | ||||
I-10 | Quercetin | 302.24 |
| 15.5(0.33) | NC | NC | ||||
DCS | 102.09 |
| 5.4(0.3) | 25(1.98) | 50(2.9) | 149.6(5.9) | 5 |
