Fig. 7

Schematic graphical presentation of the major pathway components or proteins significantly regulated in the Neisseria meningitidis (Nm) dprA mutant. Downregulated proteins are written in black text and upregulated in green. The figure illustrates: the limitation on the nutrient transport of Nm from the outside source possibly imposed by the reduced expression of ABC transporters and the subsequent effect on the Nm metabolism. The enzymes affected within the Nm core metabolism network (glycolysis, TCA cycle and electron transport chain). The less expressed enzymes involved in the production (cytochromes) and detoxification of ROS byproducts of metabolism. Components of the DNA-uptake machinery involved in the internalization of foreign DNA, proteins necessary for the integration of the internalized foreign DNA, DNA damage-repair, and replication, including the proteins required for proper division of the cell that are less expressed in the dprA mutant. IM- inner membrane, OM- outer membrane, Cyc- Cytochrome c, Cyc5- Cytochrome c5