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Table 2 The minimum inhibitory concentration and minimum bactericidal concentration of AvBD analogues

From: Novel synthetic analogues of avian β-defensin-12: the role of charge, hydrophobicity, and disulfide bridges in biological functions

Bacteria

(strain)

E. coli

(ATCC 25922)

S. Typhimurium

(ATCC 14028)

P. aeruginosa

(ATCC 27853)

S. aureus

(ATCC 29213)

Defensins

MIC-ls

MBC-ls

MIC

MIC-ls

MBC-ls

MIC

MIC-ls

MBC-ls

MIC

MIC-ls

MBC-ls

MIC

AvBD-12-A1

8

32

N/A

32

128

N/A

32

256

N/A

256

>256

N/A

AvBD-12-A2

4

16

N/A

16

64

N/A

16

32

N/A

256

256

N/A

AvBD-12-A3

4

16

128

16

64

>256

8

16

>256

128

256

>256

AvBD-12-A4

128

>256

N/A

256

>256

N/A

256

>256

N/A

>256

>256

N/A

AvBD-12-A5

64

256

N/A

256

>256

N/A

256

>256

N/A

>256

>256

N/A

AvBD-12-A6

64

256

N/A

256

>256

N/A

256

>256

N/A

>256

>256

N/A

AvBD-12/6

8

32

256

16

64

>256

64

256

>256

256

256

256

AvBD-6

4

16

128

16

64

>256

64

128

>256

256

256

256

AvBD-12

32

128

256

128

256

>256

128

>256

>256

256

256

>256